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Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling



Oxidative Stress in Vertebrates and Invertebrates: Molecular Aspects of Cell Signaling

Tahira Farooqui (Editor), Akhlaq A. Farooqui (Editor)

ISBN: 978-1-118-14811-2 October 2011 Wiley-Blackwell 416 Pages

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This volume presents a unique comparative treatment of the role oxidative stress plays in vertebrates and invertebrates in multiple organ systems with regards to cell death, development, aging, and human diseases, and anti-oxidant therapy. It offers comprehensive reviews of the current understanding of oxidative stress-mediated physiology and pathology as well as directions for future research. It also provides current information on the role of oxidative stress in neurodegenerative diseases, cardiovascular diseases, and various types of cancer mediated by oxidative stress.
Tahira Farooqui and Akhlaq A. Farooqui

Grace Y. Sun

Tahira Farooqui and Akhlaq A. Farooqui



1 Generation of Reactive Oxygen Species in the Brain: Signaling for Neural Cell Survival or Suicide 3
Akhlaq A. Farooqui

2 Free Radicals, Signal Transduction, and Human Disease 17
Klaudia Jomova and Marian Valko

3 Oxidative Stress and its Biochemical Consequences in Mitochondrial DNA Mutation-Associated Diseases: Implications of Redox Therapy for Mitochondrial Diseases 33
Shi-Bei Wu, Yu-Ting Wu, Yi-Shing Ma, and Yau-Huei Wei

4 Oxidative Stress in Kainic Acid Neurotoxicity: Implications for the Pathogenesis of Neurotraumatic and Neurodegenerative Diseases 51
Akhlaq A. Farooqui

5 Survival Strategy and Disease Pathogenesis According to the Nrf2-Small Maf Heterodimer 63
Masanobu Morita and Hozumi Motohashi

6 Caloric Restriction and Oxidative Stress 83
Jan Škrha

7 Pathogenesis of Neurodegenerative Diseases: Contribution of Oxidative Stress and Neuroinflammation 103
Tahira Farooqui and Akhlaq A. Farooqui

8 Neurosteroids in Oxidative Stress-Mediated Injury in Alzheimer Disease 117
Amandine Grimm, Ayikoe Guy Mensah-Nyagan, and Anne Eckert

9 Oxidative Stress in Adult Neurogenesis and in the Pathogenesis of Alzheimer Disease 129
Philippe Taupin

10 Oxidative Stress and Parkinson Disease 139
Kah-Leong Lim, Doyle Graham, and Xiao-Hui Ng

11 Oxidative Stress in Cardiovascular Diseases 153
Michael E. Andrades and Rodrigo Lorenzi

12 Oxidative Stress and Aging: A Comparison between Vertebrates and Invertebrates 167
Syed Ibrahim Rizvi and Kanti Bhooshan Pandey

13 Oxidative Stress-Mediated Signaling Pathways by Environmental Stressors 175
Hideko Sone and Hiromi Akanuma

14 Selenoproteins in Cellular Redox Regulation and Signaling 195
Arjun V. Raman and Marla J. Berry

15 Antioxidant Therapy and its Effectiveness in Oxidative Stress-Mediated Disorders 209
Tommaso Iannitti and Beniamino Palmieri

16 The Protective Role of Grape Seed Polyphenols Against Oxidative Stress in Treating Neurodegenerative Diseases 235
Giulio Maria Pasinetti

17 Pharmacological and Therapeutic Properties of Propolis (Bee Glue) 245
Kandangath Raghavan Anilakumar, Farhath Khanum, and Amarinder Singh Bawa


18 Endocrine Control of Oxidative Stress in Insects 261
Natraj Krishnan and Dalibor Kodri´k

19 Oxidative Stress in the Airway System of the Fruit Fly Drosophila melanogaster 271
Thomas Roeder

20 Molecular Mechanisms of Antioxidant Protective Processes in Honeybee Apis mellifera 279
Alexey G. Nikolenko, Elena S. Saltykova, and Louisa R. Gaifullina

21 Molecular Basis of Iron-induced Oxidative Stress in the Honeybee Brain: A Potential Model System of Olfactory Dysfunction in Neurological Diseases 295
Tahira Farooqui

22 Modulation of Oxidative Stress by Keap1/Nrf2 Signaling in Drosophila: Implications for Human Diseases 309
Gerasimos P. Sykiotis, M. Mahidur Rahman, and Dirk Bohmann

23 Orchestration of Oxidative Stress Responses in Drosophila melanogaster: A Promoter Analysis Study of Circadian Regulatory Motifs 327
Kuntol Rakshit and Natraj Krishnan

24 The Protective Role of Sestrins Against Chronic TOR Activation and Oxidative Stress 337
Jun Hee Lee and Ethan Bier

25 Current Advances in the Studies of Oxidative Stress and Age-Related Memory Impairment in C. elegans 347
Shin Murakami, Kelly Cabana, and Danielle Anderson

26 Oxidative Challenge and Redox Sensing in Mollusks: Effects of Natural and Anthropic Stressors 361
Julie Letendre, Franc¸ois Leboulenger, and Fabrice Durand

27 Perspective and Directions for Future Studies 377
Tahira Farooqui and Akhlaq A. Farooqui