DescriptionMany different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
P2 Purinoceptors: Historical Perspective and Classification (G. Burnstock).
P2T Purinoceptors: ADP Receptors on Platelets (S. Hourani and D. Hall).
Trophic Actions of Extracellular ATP on Astrocytes, Synergistic Interactions with Fibroblast Growth Factors and Underlying Signal Transduction Mechanisms (J. Neary).
The Diverse Series of Recombinant P2Y Purinoceptors (E. barnard, et al.).
Functional Properties of Native and Cloned P2X Receptors (A. Surprenant).
Involvement of Distinct Receptors in the Actions of Extracellular Uridine Nucleotides (J. Boeynaems, et al.).
Challenges in Developing P2 Purinoceptor-Based Therapeutics (M. Williams).