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Pain Management: Expanding the Pharmacological Options

Pain Management: Expanding the Pharmacological Options

Gary J. McCleane

ISBN: 978-1-444-30080-2 January 2009 Wiley-Blackwell 200 Pages




Conventional pharmaceutical approaches to pain management are not always successful. Using only those medications that have an official indication for a certain condition reduces substantially the chance of the patient gaining pain relief and may expose them to intolerable side effects. However evidence now exists on the use of other drugs, produced for non-pain conditions, and how they can substantially increase the chances of pain relief.

Covering the most recent developments in this field, McCleane offers an alternative solution to pain treatment when conventional treatments fail. This pioneering book proposes evidence-based alternatives to current options in pain management, using well-grounded rationales for each given treatment.

This book is an ideal reference for the specialist and non-specialist prescriber alike and for practitioners from a wide variety of disciplines. It provides the evidence required and treatment algorithms for readers to use the drugs appropriately and to explore the field if they wish.


1 Introduction.

2 Conventional Pain Treatment.

3 Using Drugs Outside Their Licensed Indication.

Part 1.

4 Topical Nitrates.

5 Topical Tricyclic Antidepressants.

6 Topical Opioids.

7 Topical Local Anesthetics.

8 Topical Glutamate Receptor Antagonists.

9 Topical, Oral, and Perineural-Adrenoreceptor Agonists.

10 Lamotrigine.

11 5HT3 Antagonists.

12 Cholecystokinin Antagonists.

13 Parenteral Anti-epileptics.

14 Intravenous Lidocaine.

15 L-Carnitine.

16 Other Pharmacological Options (Botulinum, Cimetidine, Glucosamine).

Part 2.

17 Neuropathic Pain.

18 Complex Regional Pain Syndrome.

19 Joint Pain.

20 Fracture Pain.

21 Postoperative Pain.

22 Fibromyalgia.

23 Muscle Spasm and Pain.

24 Tendinopathies.

25 Low Back Pain.

26 Cancer Pain.

Appendix: Suggested Doses and Modes of Administration of Novel Pharmacological Options.


“The author is clearly an expert in all of the topics covered in the book. It is one of the few books that offers a well informed, thoughtful discussion of the off-label use of a wide variety of drugs in the treatment of pain and is a valuable addition to the literature. This is a terrific quick reference that should be readily available in any clinic where patients with pain are managed.” (Doody's Book Reviews, November 2008)
Unique features

Pharmacological Alternatives for Pain Management

Evidence-based approach

Treatment algorithms