Skip to main content

Peptide Materials: From Nanostuctures to Applications

Peptide Materials: From Nanostuctures to Applications

Carlos Aleman (Editor) , Alberto Bianco (Editor) , Mariano Venanzi (Editor)

ISBN: 978-1-118-59241-0

Mar 2013

464 pages

$161.99

Description

Peptides are the building blocks of the natural world; with varied sequences and structures, they enrich materials producing more complex shapes, scaffolds and chemical properties with tailorable functionality. Essentially based on self-assembly and self-organization and mimicking the strategies that occur in Nature, peptide materials have been developed to accomplish certain functions such as the creation of specific secondary structures (a- or 310-helices, b-turns, b-sheets, coiled coils) or biocompatible surfaces with predetermined properties. They also play a key role in the generation of hybrid materials e.g. as peptide-inorganic biomineralized systems and peptide/polymer conjugates, producing smart materials for imaging, bioelectronics, biosensing and molecular recognition applications.

Organized into four sections, the book covers the fundamentals of peptide materials, peptide nanostructures, peptide conjugates and hybrid nanomaterials, and applications with chapters including:

  • Properties of peptide scaffolds in solution and on solid substrates
  • Nanostructures, peptide assembly, and peptide nanostructure design
  • Soft spherical structures obtained from amphiphilic peptides and peptide-polymer hybrids
  • Functionalization of carbon nanotubes with peptides
  • Adsorption of peptides on metal and oxide surfaces
  • Peptide applications including tissue engineering, molecular switches, peptide drugs and drug delivery

Peptide Materials: From Nanostructures to Applications gives a truly interdisciplinary review, and should appeal to graduate students and researchers in the fields of materials science, nanotechnology, biomedicine and engineering as well as researchers in biomaterials and bio-inspired smart materials.

Preface xiii

List of Contributors xvii

Part I Fundamentals of Peptide Materials 1

1 Physics of Peptide Nanostructures and Their Nanotechnology Applications 3
Nadav Amdursky, Peter Beker and Gil Rosenman

1.1 Introduction to Peptide Nanotubes 4

1.2 Optical Properties and Quantum Confinement of FF-based Nanostructures 8

1.3 Odd-Tensor Related Physical Properties 13

1.4 Thermal Induced Phase Transition in Peptide Nanotubes 17

1.5 Deposition Techniques of PNT 22

1.6 Applications of PNTs 29

1.7 Conclusion 32

References 33

2 Chemistry of Peptide Materials: Synthetic Aspects and 3D Structural Studies 39
Fernando Formaggio, Alessandro Moretto, Marco Crisma and Claudio Toniolo

2.1 Introduction 40

2.2 Synthesis of Difficult Peptide Sequences 40

2.3 Peptide (Amide) Bond 43

2.4 Peptide Torsion Angles 44

2.5 Peptide Secondary Structures 46

References 58

3 Conformational Aspects and Molecular Dynamics Simulations of Peptide Hybrid Materials: From Methods and Concepts to Applications 65
Carlos Alemán, Oscar Bertran, Jordi Casanovas, Juan Torras, Guillermo Revilla-López and David Zanuy

3.1 Computational Chemistry 66

3.2 Quantum Mechanical Calculations: Concepts 67

3.3 Quantum Mechanical Calculations on Hybrid Peptide Materials: Some Examples 72

3.4 NCAD: An Information Management System of Quantum Mechanical Calculations on Noncoded Amino Acids for Peptide Design 74

3.5 Molecular Mechanics Calculations: Concepts 77

3.6 Molecular Dynamics Simulations on Peptides 85

3.7 Summary 97

Acknowledgements 97

References 98

4 Peptronics: Peptide Materials for Electron Transfer 105
Emanuela Gatto and Mariano Venanzi

4.1 Introduction 106

4.2 Electron Transfer through Peptide Scaffolds in Solution 107

4.3 Electron Transfer through Supported Peptide Matrices 121

4.4 Conclusions and Perspectives 143

Acknowledgements 143

References 144

Part II Peptide Nanostructures 149

5 Molecular Architecture with Peptide Assembling for Nanomaterials 151
Shunsaku Kimura and Motoki Ueda

5.1 Introduction 151

5.2 Peptide Vesicles 152

5.3 Peptide Building Blocks 157

5.4 Peptide Architecture 159

5.5 Function of Peptide Assemblies 161

5.6 Tumor Imaging with Peptide Nanocarrier 163

5.7 Perspectives 167

References 168

6 Principles of Shape-Driven Nanostructure Design via Self-Assembly of Protein Building Blocks 171
Idit Buch, Chung-Jung Tsai, Carlos Alemán and Ruth Nussinov

6.1 Introduction 172

6.2 Self-Assembly into Preferred Shapes 172

6.3 Designing Protein Nanotubes 180

6.4 Summary and Outlook 185

Acknowledgements 186

References 186

7 Peptide-Based Soft Spherical Structures 191
K. Vijaya Krishna, Nidhi Gour and Sandeep Verma

7.1 Introduction 191

7.2 Short Peptide Sequences 192

7.3 Amphiphilic Peptides 200

7.4 Peptide–Polymer Hybrids 205

7.5 Future Outlook 209

References 211

Part III Peptide Conjugates and Hybrid Materials 217

8 Peptide-Based Carbon Nanotube Dispersal Agents 219
Anton S. Klimenko and Gregg R. Dieckmann

8.1 Introduction 220

8.2 α-Helical Surfactant Peptides 222

8.3 β-Strand Surfactant-Like Peptides 229

8.4 Extended Peptides 231

8.5 Amorphous Peptides 233

8.6 Cyclic Peptides 234

8.7 Summary and Outlook 237

Acknowledgements 239

References 239

9 Nanosized Vectors for Transfection Assembled from Peptides and Nucleic Acids 247
Burkhard Bechinger

9.1 Introduction 248

9.2 Condensation of Nucleic Acids by Cationic Peptides and Other Macromolecules 250

9.3 The Size and Shape of Transfection Complexes 251

9.4 Cellular Targeting by Specific Ligands 252

9.5 Enhancing the Cellular Uptake of Nanocomplexes 252

9.6 Assuring Endosomal Escape 253

9.7 A Family of Multifunctional Peptide Sequences 255

9.8 Delivery to the Nucleus and Other Intracellular Compartments 257

9.9 Combining Different Functionalities into Complex Nanovectors 257

Acknowledgements 259

References 259

10 Properties of Disubstituted Ferrocene–Peptide Conjugates: Design and Applications 265
Sanela Martiæ, Samaneh Beheshti and Heinz-Bernhard Kraatz

10.1 Introduction 266

10.2 Structural Considerations and Properties 266

10.3 Fc–Peptides to Probe Interactions 274

10.4 Conclusions 283

References 284

11 Mechanisms of Adsorption of Short Peptides on Metal and Oxide Surfaces 289
Vincent Humblot, Jessem Landoulsi and Claire-Marie Pradier

11.1 Introduction 290

11.2 Why Studying the Interaction of Short Peptides with Solid Surfaces? 291

11.3 Metal and Oxide Surfaces 292

11.4 Factors Influencing Peptide Adsorption 293

11.5 Adsorption at the Solid/Gas interface 295

11.6 Adsorption at the Solid/Liquid Interface 303

11.7 Conclusions and Guidelines for the Future 307

References 308

Part IV Applications of Peptide Materials 313

12 Bioactive Rosette Nanotubes for Bone Tissue Engineering and Drug Delivery 315
Rachel L. Beingessner, Alaaeddin Alsbaiee, Baljit Singh, Thomas J. Webster and Hicham Fenniri

12.1 Introduction 316

12.2 Rosette Nanotubes (RNTs) 317

12.3 Applications of RNTs in Bone Tissue Engineering 328

12.4 RNTs for Drug Delivery 340

12.5 Conclusions 349

References 350

13 Peptide Secondary Structures as Molecular Switches 359
Fernando Formaggio, Alessandro Moretto, Marco Crisma and Claudio Toniolo

13.1 Introduction 360

13.2 Classical Secondary Structures Switches 360

13.3 Recently Discovered Secondary Structure Switches 365

13.4 Conclusions 376

References 378

14 Peptide Nanostructured Conjugates for Therapeutics: The Example of P140 Peptide for the Treatment of Systemic Lupus Erythematosus 385
Yves Frère, Louis Danicher and Sylviane Muller

14.1 Introduction 386

14.2 Noninvasive Routes of Peptide Administration 387

14.3 Encapsulation of Peptides and Proteins for Oral Delivery 390

14.4 P140 Peptide Nanostructured Complex for the Treatment of Systemic Lupus Erythematosus 399

14.5 General Comments 412

Acknowledgements 412

References 412

15 Identification and Application of Polymer-Binding Peptides 417
Toshiki Sawada and Takeshi Serizawa

15.1 Introduction 417

15.2 Biological Identification of Material-Binding Peptides 419

15.3 Recognition of Polymer Stereoregularity by Peptides 421

15.4 Recognition of Other Polymer Nanostructures by Peptides 424

15.5 Applications of Polymer-Binding Peptides 426

15.6 Summary 428

References 428

Index 435