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Pharmacological Treatment of Alzheimer's Disease: Molecular and Neurobiological Foundations

Hardcover

$310.00

Pharmacological Treatment of Alzheimer's Disease: Molecular and Neurobiological Foundations

Jorge D. Brioni (Editor), Michael W. Decker (Editor)

ISBN: 978-0-471-16758-7 March 1997 549 Pages

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Description

Prominent Alzheimer's investigators provide a comprehensive and balanced overview of the neuropharmacological basis for therapeutics in this devastating disease. Divided into three parts, the book begins with basic research on the neurobiology of cognitive function, offering relevant information on the way the brain encodes and stores data. The second segment explores the molecular aspects of Alzheimer's Disease (AD), emphasizing investigations of possible etiological factors. In the final section, a variety of issues important in developing treatments are discussed including cholinergic-based treatments, the role of neuroinflammin in AD and the therapeutic potential of anti-inflammatory agents.
Partial table of contents:

NEUROBIOLOGY OF COGNITION.

Structure and Dynamics of Multiple Memory Systems in Alzheimer's Disease (R. Kesner & M. Ragozzino).

Monoamine and Acetylcholine Influences on Higher Cognitive Functions in Nonhuman Primates: Relevance to the Treatment of Alzheimer's Disease (A. Arnsten & C. van Dyck).

Neuropsychological Features of Alzheimer's Disease (D. Salmon).

MOLECULAR ASPECTS OF ALZHEIMER'S DISEASE.

Normal Brain Aging and Alzheimer's Disease Pathology (R. Grewal & C. Finch).

Neurofibrillary Tangles in Alzheimer's Disease: Clinical and Pathological Implications (C. Clark, et al.).

ALZHEIMER'S DRUG DISCOVERY AND DEVELOPMENT.

Use of CSF-Based Markers in the Diagnosis of Alzheimer's Disease (P. Seubert, et al.).

Development of Muscarinic Agonists for the Symptomatic Treatment of Alzheimer's Disease (J. Jaen & R. Schwarz).

Conceptual Issues in Research on Inflammation and Alzheimer's Disease (J. Rogers).

Index.