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Phosgenations: A Handbook

Livius Cotarca, Heiner Eckert

ISBN: 978-3-527-60503-3 March 2006 668 Pages



In this manual, the authors compare the range of applications for phosgene with that of the alternative compounds, dealing in detail with the possible uses of diphosgene, triphosgene, carbon dioxide, organic carbonates, oxalylchloride and many other alternative materials used in synthesis. However, they clearly point out those cases where phosgene continues to have the advantage. The result is a mine of information for synthetic chemists working in industry and academia faced with the question of where the toxic phosgene can be replaced by an unproblematic compound - including the safety phosgenation.
Introduction. Classification of Phosgene Organic Reactions
Structural Properties of Phosgene and 'Pseudophosgene' Compounds
Thermodynamic of Phosgene Reactions
Thermal, Chemical (Nucleophilic) and Catalytic Induced Dissociation
Phosgenes vs. Phosgene Substitutes Reactivity
Phosgenes vs. Phosgene Substitutes Reactions
Specific Synthetic Applications of Phosgene vs. Phosgene Substitutes
Sources of Phosgene
Synthesis of Phosgene Substitutes
Safety Aspects and Environmental Impact
Monitoring of Phosgene and Phosgene Substitutes. Analytical Methods
Outlook and Conclusions
"The encyclopaedic nature of this book, combined with its critical, informed, and comprehensive approach, makes it a very valuable source for synthetic chemists in academia and in industry."

Peter L. Spargo
Organic Research Process and Development