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Phosphorus Ligands in Asymmetric Catalysis: Synthesis and Applications

Phosphorus Ligands in Asymmetric Catalysis: Synthesis and Applications

Armin Börner (Editor)

ISBN: 978-3-527-31746-2

Apr 2008

1546 pages

Select type: Hardcover

In Stock

$825.00

Description

With its list of contributors reading like a who's who, this is the ultimate standard reference on phosphorus in catalysis. Clearly divided into substance classes and spanning three volumes, it provides readers with an excellent introduction to the multitude of applications, backed by examples of optimal solutions.
A definite must-have for all chemists working in synthetic chemistry, ranging from natural product synthesis to the production of pharmaceuticals.
Introduction
TRIVALENT PHOSPHOROUS LIGANDS IN METAL-CATALYZED REACTIONS
Chiral Monodentate Phosphorous Ligands
Chiral Bidentate Phosphorous Ligands
Chiral Polyphosphorous Ligands
DYNAMIC PROCESSES OF P-LIGAND COMPLEXES
Chiral Secondary Phosphine Oxides and Heteroatom-Substituted Secondary Phosphine Oxides as Preligands
Catalysts with Chiral Self-Assembling P-Ligands
P-Ligands with Additional Functional Groups -
Concepts of Secondary Interactions and Hemilability
CHIRAL LIGANDS FOR REACTIONS IN ALTERNATIVE MEDIA
Ligands for Catalytic Reactions in Aqueous Systems
Ligands for Catalytic Reactions in Fluorous Systems
Ligands for Catalytic Reactions in Ionic Liquids
Covalently Anchored P-Ligands and Catalysts
Micelle-Based Chiral P-Ligands
Dendritic Catalysts Based P-Ligands
Noncovalently Anchored Catalysts Based on Chiral Phosphine Ligands
P-LIGANDS BOUND TO BIOMOLECULES
P-Ligands Bound to Proteins: Artificial Metalloenzymes
P-Ligands Bound to Peptides
MIXTURES OF MONODENTATE P-LIGANDS IN STEREO- AND REGIOSELECTIVE TRANSITION METAL CATALYSIS
The General Concept of Using Mixtures of Monodentate Ligands
Controlling Enantioselectivity by Using Mixtures of Monodentate P-Ligands
CHIRAL TRIVALENT PHOSPHOROUS LIGANDS CATALYSTS
Kinetic Resolution with Phosphine Organocatalysts
Desymmetrization
Asymmetric Catalytic Reactions of Prochiral Compounds with Phosphine Organocatalysts
GENERAL METHODS FOR THE SYNTHESIS OF CHIRAL TPC
Synthesis of P-Stereogenic Phosphines Via Enantioselective Alkylation
Synthesis of P-Stereogenic Phosphorous Compounds Based on Chiral Aminoalcohols as Chiral Auxiliary
Practical Routes to Chiral Phospholanes
Chiral Ligands Made by Asymmetric Catalysis
Phosphine Boranes and Related Trivalent P-Compounds as Intermediates in the Syntheses of Chiral Ligands and Organocatalysts
Parallel Synthesis of Chiral P-Ligands
CONTROLLING REGIO- AND STEREOCHEMISTRY IN METAL-CATALYZED AND METAL-MEDIATED REACTIONS WITH THE AID OF SUBSTRATE-BOUND REAGENT-DIRECTING PHOSPHINE GROUPS
Design and Preparation of the Reagent-Directing o-DPPB Group
Application in Directed Hydroformylation
o-DPPB-Directed Atropdiastereoselective Biarylcoupling
o-DPPB-Directed Palladium-Catalyzed Allylic Substitution
o-DPPB- and o-DPPB-Directed Allylic Substitution with Organocopper Reagents
CHARACTERIZATION OF P-LIGANDS METAL COMPLEXES
NMR Spectroscopic Methods
Properties of Phosphorous Ligands
INDUSTRIAL ASPECTS
The Role of Chiral Phosphines as Ligands
The Difficult Task of Finding the Right Chiral Catalyst
The Major Suppliers of Chiral Ligands and Related Services
Commercially Available Chiral Ligands with Established Industrial Performance
Technological Aspects
Handling of IP Rights and Licensing for Production