Skip to main content

Plasmids for Therapy and Vaccination

Plasmids for Therapy and Vaccination

Martin Schleef (Editor)

ISBN: 978-3-527-61284-0 July 2008 Wiley-Blackwell 307 Pages




This is the first book specializing in plasmids and their biomedical use, including all relevant aspects of production, applications, quality, and regulations. Readers will discover clinical applications for the wide range of preventive and therapeutic applications using plasmid DNA. The book describes modified vector systems based on plasmids, as well as the potency of genomic research and vector design by informatics. Using the example of fish vaccination, the application of DNA vaccination in veterinary health care is reviewed, followed by a detailed overview of plasmid production technology on an industrial scale. Finally, the book considers regulatory and quality assurance aspects of such new drugs plus thire market potential.
The Biology of Plasmids
Structures of Plasmid DNA
Genetic Vaccination with Plasmid Vectors
A Liposomal iNOS-Gene Therapy Approach to Prevent Neointimal Lesion Formation in Procine Femoral Arteries
Immunotherapy of Chronic Hepatitis B by pCMV-S2S DNA Vaccine
pSG.MEPfTRAP- A First Generation Malaria DNA Vaccine Vector
Polyvalent Vectors for Coexpression of Multiple Genes
Form Follows Function: The Design of Minimalistic Immunogenically Defined Gene Expression Constructs
Synthetic Genes for Prevention and Therapy: Implications on Safety and Efficacy of DNA Vaccines and Lentiviral Vectors
Plasmids in Fish Vaccination
From Research Data to Clinical Trials with Plasmid DNA
Plasmid Manufacturing -
An Overview
Quality Control of pDNA
From Research Data to Clinical Trials
Market Potential for DNA Therapeutics