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Plasminogen-Related Growth Factors

Plasminogen-Related Growth Factors

Gregory R. Bock (Editor), Jamie A. Goode (Editor)

ISBN: 978-0-470-51547-1

Apr 2008

268 pages

Select type: E-Book



A timely volume dealing with the evolutionary and structural links between the clotting and fibrinolytic proteins and plasminogen-related growth factors. The role of individual domains for enzymatic proteins and plasminogen-related growth factors is also comprehensively examined.
Evolution of Vertebrate Fibrin Formation and the Process of its Dissolution;
Evolution of Plasminogen-Related Growth Factors and their Receptors;
Domain Structure and Interactions in Plasminogen;
Structure and Function of Plasminogen: Reconstitution of Microplasminogen and Microplasmin from Isolated Fragments;
Protein Engineering of HGF/SF;
Met-HGF/SF: Tumorigenesis, Invasion and Metastasis;
Signalling Through PRGF Receptors;
Plasminogen/Plasmin as a Mediator of Extracellular Proteolysis;
HGF/SF and Met in Chick Development;
Essential Roles of Scatter Factor/Hepatocyte Growth Factor (SF/HGF) and the C-Met Receptor During Mouse Development;
Action of Macrophage-Stimulating Protein (MSP) on Macrophages and Keratinocytes;
HGF/SF in Angiogenesis;
The Organotrophic Function of HGF and its Therapeutic Potential;
Role of SF/Gab-1 in Morphogenesis and Metastasis of Mammary Epithelial Cells.