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Polyfunctional Cytokines: IL-6 and LIF

Polyfunctional Cytokines: IL-6 and LIF

Gregory R. Bock (Editor), Joan Marsh (Editor), Kate Widdows (Editor)

ISBN: 978-0-470-51427-6 April 2008 290 Pages




Experts from a variety of areas compare and discuss IL-6 and LIF in order to provide a new understanding of their modes of action, the significance of their polyfunctionalization--why the body chooses to use one molecule to regulate various cell types--and their functional overlap. Covers such topics as actions of IL-6 and LIF on lymphoid populations, on megakaryocyte and platelet production, on bone metabolism, their effects on leukemic cells and much more. Includes contributions from researchers working on a variety of cell types and organ systems along with potential clinical applications regarding these two factors.
Partial table of contents:

The Molecular Biology of Interleukin 6 and Its Receptor (T. Kishimoto, et al.).

The Action of Interleukin 6 on Lymphoid Populations (L. Aarden & C. van Kooten).

Further Studies of the Distribution of CDF/LIF mRNA (P. Patterson & M.-J.


Leukemia Inhibitory Factor and Bone Cell Function (T. Martin, et al.).

The Role of Interleukin 6 in Plasmacytomagenesis (T. Hirano, et al.).

Distribution and Binding Properties of Receptors for Leukemia Inhibitory Factor (D. Hilton, et al.).

Reconstitution of High Affinity Leukemia Inhibitory Factor (LIF) Receptors in Hemopoietic Cells Transfected with the Cloned Human LIF Receptor (D. Gearing, et al.).