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Polyketides and Non-Ribosomal Peptides: Biosynthesis, Synthesis, Mode of Action

Polyketides and Non-Ribosomal Peptides: Biosynthesis, Synthesis, Mode of Action

Andreas Kirschning, Markus Kalesse

ISBN: 978-3-527-69781-6

Mar 2020

330 pages

$164.99

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Description

Adopting a novel approach to the topic that links the contents of both biosynthesis and chemical synthesis through mechanistic examination, this book provides a modern perspective on polyketides and non-ribosomal peptides.
Following a general introduction to the field of natural products, the internationally recognized expert authors combine biosynthesis and enzymology with total synthesis strategies towards both compound classes. They also describe the mode of action for the most important polyketide and non-ribosomal peptide representatives.
With its unique scope, this is an essential guide for academics and professionals involved in the chemical synthesis, biosynthesis or metabolic engineering of natural products, as well as drug development.
1. Introduction to Natural Products

2. Principal Biosynthetic Transformations
2.1 Enzymatic Transformations
2.2 Cofactors
2.3 Techniques of Deciphering Biosynthetic Pathways

3. Biosynthesis of Polyketides and Non-Ribosomal Peptides
3.1 Fatty acids
3.2 Polyketides
3.3 Non-Ribosomal Peptides
3.4 Genetic Aspects

4. Chemical Synthesis of Polyketides and Non-Ribosomal Peptides
4.1 Introduction
4.2 Polyketide Synthesis
4.3 NMR Methods
4.4 Biological Properties and Application in Medicine of Polyketides
4.5 Synthesis of Non-Ribosomal Peptides
4.6 Chemical Synthesis of beta-Lactam Antibiotics
4.7 Biological Properties and Application in Medicine of Non-Ribosomal Peptides
4.8 Semisynthesis

5. Metabolic Engineering of Metabolic Pathways

6. Summary and Outlook