DescriptionExamines the establishment of the germ layers and other cell lineages in the early embryo including details of cell movements during the beginning stages of primitive streak formation. Discusses patterns of gene expression during the development of such tissues as the limb bud, skeletal, muscle and the central nervous systems placing special emphasis on commitment to particular cell types. Although it concentrates on the mouse as an example of mammalian development--chick, amphibian and Drosophila embryogenesis are employed whenever these organisms are more applicable to the study of a particular problem.
Clonal Analysis of Cell Fate During Gastrulation and Early Neurulation in the Mouse (K. Lawson & R. Pedersen).
Use of Chimeras to Study Gene Function in Mesodermal Tissues During Gastrulation and Early Organogenesis (R. Beddington, et al.).
Action of the Brachyury Gene in Mouse Embryogenesis (B. Herrmann).
Molecular Mechanisms of Pattern Formation in the Vetebrate Hindbrain (M. Nieto, et al.).
Myogenesis in the Mouse (M. Buckingham, et al.).
Development of the Skeletal System (R. Balling, et al.).
Development of the Left--Right Axis (N. Brown, et al.).
Use of Embryonic Stem Cells to Study Mutations Affecting Postimplantation Development in the Mouse (E. Robertson, et al.).
Genetic Manipulation of the Mouse via Gene Targeting in Embryonic Stem Cells (A. Bradley, et al.).