Chapter 1: Aliphatic Nucleophilic Substitution (Jade D. Nelson).
Chapter 2: Addition to Carbon-Heteroatom Multiple Bonds (Rajappa Vaidyanathan and Carrie Brockway Wager).
Chapter 3: Addition to CarbonCarbon Multiple Bonds (John A. Ragan).
Chapter 4: Nucleophilic Aromatic Substitution (Stéphane Caron and Arun Ghosh).
Chapter 5: Electrophilic Aromatic Substitution (Stéphane Caron).
Chapter 6: Selected Metal-mediated cross-coupling reactions (Stéphane Caron, Arun Ghosh, Sally Gut Ruggeri, Nathan D. Ide, Jade D. Nelson, and John A. Ragan).
Chapter 7: Rearrangements (David H. B. Ripin).
Chapter 8: Eliminations (Sally Gut Ruggeri).
Chapter 9: Reductions (Sally Gut Ruggeri, Stéphane Caron, Pascal Dubé, Nathan D. Ide, Kristin E. Price, John A. Ragan, and Shu Yu).
Chapter 10: Oxidations (David H. Brown Ripin).
Chapter 11: Selected Free Radical Reactions (Nathan D. Ide).
Chapter 12: Synthesis of ""Nucleophilic"" Organometallic Reagents (David H. Brown Ripin).
Chapter 13: Synthesis of Common Aromatic Heterocycles (Stéphane Caron).
Chapter 14: Access to Chirality (Robert W. Dugger).
Chapter 15: Synthetic Route Development of Selected Contemporary Pharmaceutical Drugs (Stéphane Caron).
Chapter 16: Green Chemistry (Juan C. Colberg).
Chapter 17: Naming Carbocycles and Heterocycles (Heather N. Frost and David H. B. Ripin).
Chapter 18: pKa (David H. Brown Ripin).
Chapter 19: General Solvent Properties (Stéphane Caron).
Chapter 20: Practical Chemistry Concepts Tips for the Practicing Chemist or Things They Don't Teach You in School (Sally Gut Ruggeri).
“The last sentence by editor Caron is an appropriate conclusion: “Building each chapter … served as an excellent chemistry refresher course for the authors, and we learned a lot of new chemistry in the process.” Chemists everywhere will applaud their efforts and.” (Angewandte Chemie, 2012)
""The book is extremely good value, partly because it is not available in hardback and whilst this may please budget-holders initially, it also is another good reason for looking forward to a second edition. . . Overall, apart from one or two very minor complaints, this book is highly recommended, in fact it should be a must for all practising synthetic organic chemists."" (Organic Process Research & Development Journal, 2011)
""...an emphasis on practicality, scalability and efficiency... I would imagine this will be a popular teaching text in universities but it should also be read by process chemists for an insight into good synthetic organic chemistry and route design. It looks excellent value for money."" (Scientific Update, 2011)