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Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Sebastien Vidal

ISBN: 978-3-527-34010-1

Jan 2019

528 pages

Select type: Hardcover




A unique overview of the most important protecting group strategies in carbohydrate chemistry

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry provides a detailed account of key strategies and methodologies for the protection of carbohydrates. Divided into two parts, the first focuses on groups that are used best to protect a specific position on a carbohydrate. In the second part, specific carbohydrate residues or compounds are discussed in the context of a specific protecting group strategy used to reach the desired regioisomer. This important book:

-Features chapters on protecting groups at the primary and secondary positions of carbohydrates
-Describes protecting group strategies towards sialic acid derivatives, glycofuranoses, sulfated glycosaminoglycans, and cyclodextrins
-Provides information on automated glycan assembly
-Includes a chapter on the industrial scale synthesis of heparin analogs

Written by a team of leaders in the field, Protecting Groups: Strategies and Applications in Carbohydrate Chemistry is an indispensable guide for academics and industrial researchers interested in carbohydrate and natural product synthesis, pharmaceutical chemistry, and biochemistry.
1. Protecting Group Strategies in Carbohydrate Chemistry (A. G. Volbeda, G. A. van der Marel, J. D. C. Codée)
2. Protecting Groups at the Primary Position of Carbohydrates (M. Donnier-Maréchal, S. Vidal, M. Fiore)
3. Protecting Groups at the Secondary Position of Carbohydrates (S. Vidal, P. G. Goekjian)
4. Regioselective Protection at the Secondary Position of Carbohydrates with Acyclic Protecting Groups (P. G. Goekjian, S. Vidal)
5. Protecting Groups at the Anomeric Position of Carbohydrates (C. Sakonsinsiri, W. Bruce Turnbull)
6. N-Protecting Groups for 2-Amino-2-Deoxy-Glycosides (S. Vidal)
7. One-Pot Multi-Step Regioselective Protection of Carbohydrates Catalyzed by Acids (J.-M. Beau, Y. Bourdreux, G. Despras, A. Gouasmat, G. San Jose, D. Urban, B. Vauzeilles)
8. Acyl Migrations in Carbohydrate Chemistry (F. S. Ekholm, R. Leino)
9. De Novo Asymmetric Synthesis of Oligosaccharides Using Atom-Less Protecting Groups (D. Ray, G. A. O'Doherty)
10. Protecting Group Strategies for Sialic Acid Derivatives (H. Amarasekara, S. Buda, A. Reddy Mandhapati, D. Crich)
11. Strategies Towards Protection of 1,2- and 1,3-Diols in Carbohydrate Chemistry (M. Schuler, A. Tatibouët)
12. Protecting Group Strategies Towards Glycofuranoses (V. Ferrières, L. Legentil, L. Lemiègre)
13. Cyclodextrin Chemistry via Selective Protecting Group Manipulations (J. M. Benito, J. M. García Fernández)
14. Protecting Group Strategies Towards Sulfated Glycosaminoglycans (H. Ledru, P. Matton, J.-M. Mallet, C. Lopin-Bon)
15. Applications of Fluorous and Ionic Liquid Tags in Oligosaccharide Synthesis (I. Sittel, M. Carmen Galan)
16. Orthogonally Protected Building Blocks for Automated Glycan Assembly (F. Pfrengle, P. H. Seeberger)
17. Kilogram-Scale Production of Synthetic Heparin Analogs (P. Trouilleux, P. Potier, P.-A. Driguez)