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Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Protecting Groups: Strategies and Applications in Carbohydrate Chemistry

Sebastien Vidal

ISBN: 978-3-527-69702-1

Oct 2018

320 pages


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Written by a team of world-class leaders from academia and industry, this is a unique overview of the most important protecting group strategies in modern carbohydrate chemistry.
Clearly divided into two parts, the first focuses on those groups best used to protect a specific position on a carbohydrate. The second part then discusses specific carbohydrate residues or compounds in the context of a protecting group strategy used to reach the desired regioisomer. The whole is rounded off by chapters on case studies and industrial scale synthesis of oligosaccharides through modern protecting group chemistry.
By providing strategies and synthetic applications, this is an indispensable guide for both beginners and specialists working in carbohydrate synthesis, natural product chemistry, pharmaceutical chemistry, and biochemistry.
1) Protecting Groups at the Primary Position of Carbohydrates
2) Protecting Groups at the Secondary Position of Carbohydrates
3) Protecting Groups at the Anomeric Position of Carbohydrates
4) Strategies Towards Protection of 1,2- and 1,3-Diols
5) Protection of the Amine Functionality in Amino-Glycosides
6) Protecting Group Strategies for Glycuronic Acids
7) Protecting Group Strategies for Sialic Acid Derivatives
8) Protecting Group Strategies for Cyclodextrins
9) Protecting Group Strategies towards Glycofuranoses
10) Protecting Group Strategies towards Sulfated Glycosaminoclycans
11) A Case Study of Protecting Groups for the Synthesis of a Vaccine Antigen
12) Application of Ionic Liquid and Fluorous Tags for Oligosaccharide Synthesis
13) Acyl Migrations in Carbohydrate Chemistry
14) Orthogonally Protected Monosaccharides and Industrial Applications in Solid Phase Synthesis
15) Industrial Scale Synthesis of Oligosaccharides through Modern Protecting Group Chemistry