This volume provides, at postgraduate student level, an accessible introduction to a topic of central importance in organic synthesis. It covers the main functional groups requiring protection in organic synthesis, explaining why a particular protecting agent works and how an agent should be chosen. Emphasis is placed on what a protecting group is doing chemically to the structure that it is protecting. Attention is given to removal of the protecting group.
This is a clear and thoughtful book, which concentrates on explaining the chemistry. It also provides a convenient point of entry to the primary literature.
Table of contents
Introduction; The protection of alcohols; The protection of aldehydes and ketones; The protection of carboxylic acids; The protection of the amino group; The protection of thiols; The protection of unsaturated systems; Some experimental methods; Some common abbreviations for protecting groups and reagents; Bibliography and references; Index.