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Protein Degradation: The Ubiquitin-Proteasome System, Volume 2

Protein Degradation: The Ubiquitin-Proteasome System, Volume 2

R. John Mayer (Editor), Aaron J. Ciechanover (Editor), Martin Rechsteiner (Editor)

ISBN: 978-3-527-62021-0

Jan 2008

300 pages


The second volume in a new series dedicated to protein degradation, this book discusses the mechanism and cellular functions of targeted protein breakdown via the ubiquitin pathway.
Drawing on the combined knowledge of the world's leading protein degradation experts, this handy reference compiles information on the proteasome-mediated degradation steps of the ubiquitin pathway. In addition to proteasomal function and regulation, it also presents the latest results on novel members of the ubiquitin superfamily and their role in cellular regulation.
Further volumes in the series cover the function of ubiquitin-protein ligases, and the roles of the ubiquitin pathway in regulating key cellular processes, as well as its pathophysiological disease states.
Required reading for molecular biologists, cell biologists and physiologists with an interest in protein degradation.
Degrons: signals and sites for ubiquitylation
The proteasome portal and regulation of proteolysis
PAN and the proteasome
Ubiquitin domain proteins
MEKK1: dual function as a protein kinase and a ubiquitin protein ligase
HECT domain ubiquitin protein ligases
UCRP: ubiquitin cross-reactive protein
SUMOs and their function in the cell
Functions of the ubiquitin-proteasome pathway
Molecular Chaperones and the ubiquitin/proteasome system
Dissecting intracellular proteolysis using small molecule inhibitors and molecular probes
Electron microscopy of compartmentalised proteases
Molecular dissection of autophagy in yeast
""... a comprehensive chapter on the structure of large, self-compartmentalizing proteases ... gives an overview how complex these 'molecular machines' are that keep our cells clean. The individual chapters are followed by extensive references, and this will quarantee immediate guided access to the important literature. In summary, the book provides much more than anyone could assemble from Pubmed in a meaningful way to get informed appropriately.""
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""The series - when completed - is likely to become a comprehensive work of reference on the ubiquitin/proteasome system.""