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Protein Synthesis and Ribosome Structure: Translating the Genome

Protein Synthesis and Ribosome Structure: Translating the Genome

Knud H. Nierhaus (Editor), Daniel Wilson (Editor)

ISBN: 978-3-527-60343-5 January 2006 597 Pages


Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology.
In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.
History of Protein Biosynthesis and Ribosome Research (H.-J. Rheinberger)
Structure of the Ribosome (G. Blaha)
Assembly of the Prokaryotic Ribosome (K. H. Nierhaus)
Eukaryotic Ribosome Synthesis (D. Lafontaine)
tRNA: Structure and function (V. Marquéz and K. H. Nierhaus)
Aminoacylations of tRNAs: Record-keepers for the Genetic Code (L. Ribas de Pouplana and P. Schimmel)
mRNA Decay and RNA-degrading Machines in Prokaryotes and Eukaryotes (A. J. Carpousis and M. Dreyfus)
tRNA Locations on the Ribosome (K. Nierhaus)
Initiation of Protein Synthesis in Eubacteria (D. N. Wilson)
Mechanism and Regulation of Protein Synthesis Initiation in Eukaryotes (T. E. Dever, A. G. Hinnebusch and N. Sonenberg)
The Elongation Cycle (K. H. Nierhaus)
Termination and Ribosome Recycling (D. N. Wilson)
The Mechanism of Recoding in Pro- and Eukaryotes (E. S. Poole, L. L. Major, A. G. Cridge and W. P. Tate)
Regulation of Ribosome Biosynthesis in Escherichia coli (M. Iskakova, S. R. Connell, K. H. Nierhaus)
Antibiotics and the Inhibition of Ribosome Function (D. N. Wilson)
The Work of Chaperones (J.H. Alix )
"...a manageable and readable volume...a useful resource for everybody with an interest in protein synthesis."

Chemistry and Industry, Vol.2, No.2, February 2005