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Proteomics in Drug Research


From skillful handling of the wide range of technologies to successful applications in drug discovery -- this handbook has all the information professional proteomics users need.
Edited by experts working at one of the hot spots in European proteomic research, the numerous contributions by experts from the pharmaceutical industry and public proteomics consortia to provide the necessary perspective on current trends and developments in this exciting field.
Following an introductory chapter, the book moves on to proteomic technologies, such as protein biochips, protein-protein interactions, and proteome analysis in situ. The section on applications includes bioinformatics, Alzheimer's disease, neuroproteomics, plasma and T-cell proteomics, differential phosphoproteome analysis and biomarkers, as well as pharmacogenomics.
Invaluable reading for medicinal and pharmaceutical chemists, gene technologists, molecular biologists, and those working in the pharmaceutical industry.
Administrative Optimization of Proteomics Networks for Drug Development
Proteomic Data Standardization, Deposition and Exchange
Difference Gel Electrophoresis (DIGE): the Next Generation of Two-Dimensional Gel Electrophoresis for Clinical Research
Biological Mass Spectrometry: Basics and Drug Discovery Related Approaches
Multidimensional Column Liquid Chromatography (LC) in Proteomics
Peptidomics Technologies and Applications in Drug Research
Protein Biochips in the Proteomic Field
Current Developments for the In Vitro Characterization of Protein Interactions
Molecular Networks in Morphologically Intact Cells and Tissue-Challenge for Biology and Drug Development
From Target to Lead Synthesis
Differential Phosphoproteome Analysis in Medical Research
Biomarker Discovery in Renal Cell Carcinoma Applying Proteome-Based Studies in Combination with Serology
Studies of Drug Resistance Using Organelle Proteomics
Clinical Neuroproteomics of Human Body Fluids: CSF and Blood Assays for Early and Differential Diagnosis of Dementia
Proteomics in Alzheimer's Disease
Cardiac Proteomics
Innovation Processes
"The scope is broad, encompassing administrative, scientific, and marketing components….this book can certainly find a place in the library of any organization that makes use of proteomics." (Journal of Medicinal Chemistry, December 14, 2006)