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Reactive Intermediate Chemistry

Reactive Intermediate Chemistry

Robert A. Moss (Editor), Matthew S. Platz (Editor), Maitland Jones Jr. (Editor)

ISBN: 978-0-471-23324-4

Jan 2004

1084 pages

In Stock



Reactive Intermediate Chemistry presents a detailed and timely examination of key intermediates central to the mechanisms of numerous organic chemical transformations. Spectroscopy, kinetics, and computational studies are integrated in chapters dealing with the chemistry of carbocations, carbanions, radicals, radical ions, carbenes, nitrenes, arynes, nitrenium ions, diradicals, etc. Nanosecond, picosecond, and femtosecond kinetic realms are explored, and applications of current dynamics and electronic structure calculations are examined.

Reactive Intermediate Chemistry provides a deeper understanding of contemporary physical organic chemistry, and will assist chemists in the design of new reactions for the efficient synthesis of pharmaceuticals, fine chemicals, and agricultural products. Among its features, this authoritative volume is:

  • Edited and authored by world-renowned leaders in physical organic chemistry.
  • Ideal for use as a primary or supplemental graduate textbook for courses in mechanistic organic chemistry or physical chemistry.
  • Enhanced by supplemental reading lists and summary overviews in each chapter.


1. Carbocations (R.A. McClelland).

2. Crossing the Borderline Between SN1 and SN2 Nucleophilic Substitution at Aliphatic Carbon(T.L. Amyes, et al.).

3. Carbanions (S. Gronert).

4. Radicals (M. Newcomb).

5. Non-Kekul Molecules as Reactive Intermediates (J.A. Berson).

6. Organic Radical Ions (H.D. Roth).

7. Singlet Carbenes (M. Jones Jr. and R.A. Moss).

8. Stable Singlet Carbenes (G. Bertrand).

9. Triplet Carbenes (H. Tomioka).

10. Atomic Carbon (P.B. Shevlin).

11. Nitrenes (M.S. Platz).

12. Synthetic Carbene and Nitrene Chemistry (M.P. Doyle).

13. Nitrenium Ions (D.E. Falvey).

14. Silylenes (W. Ando and N. Tokitoh).

15. Strained Hydrocarbons: Structures, Stability, and Reactivity (K.B. Wiberg).

16. Arynes (M. Winkler, et al.).


17. Matrix Isolation (T. Bally).

18. Nanosecond Laser Flash Photolysis: A Tool for Physica l Organic Chemistry (J.C. Scaiano).

19. The Picosecond Realm (E. Hilinski).

20. Reactions on the Femtosecond Time Scale (J.E. Baldwin).

21. Potential Energy Surfaces and Reaction Dynamics (B.K. Carpenter).

22. The Partnership Between Electronic Structure Calculations and Experiments in the Study of Reactive Intermediates (W.T. Borden).


...impressive reference...would be invaluable to any scientist whose project it is to understand the degradation pathway of a new chemical entity."" (Pharmaceutical Development & Technology, February 2005)

""This is truly an excellent book. The editors…have a reputation as gifted scientific writers…the graphics are also excellent, with a common format used throughout the entire book."" (Journal of the American Chemical Society, August 18, 2004)

""…this is a very nice book, which is an absolute must for every chemist concerned with reactive intermediates.” (Angewandte Chemie International Edition, August 6, 2004)

""This book, which is well-organized and contains an extensive index, would be an indispensable resource for graduate students and professionals in academia or industry.” (E-STREAMS, July 2004)

""An excellent and up-to-date resource for graduate students and practicing organic chemists. Highly recommended."" (Choice, June 2004, Vol. 41 No. 10)