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Reactive Intermediates: MS Investigations in Solution

Reactive Intermediates: MS Investigations in Solution

Leonardo S. Santos (Editor), Christie G. Enke (Foreword by)

ISBN: 978-3-527-62873-5

Nov 2009

341 pages

$153.99

Description

During the last two decades there has been considerable growth in the development of electrospray ionization mass spectrometry (ESI-MS) as a practical method in the study of reaction mechanisms. This method allows the interception and characterization of key intermediates, either as transient species or as protonated/deprotonated forms of neutral species by API-MS. The outstanding features and advantages of ESI-MS make it one of the most suitable tools for the fast screening of intermediates directly from solution, providing hitherto unavailable chemical information to organic chemists.
This monograph provides an overview of the mechanisms involved in ESI-MS, the historical perspectives before looking further in-depth at specific reactions and intermediates. Written by researchers in the field, this book is an unique resource for the understanding of this cutting-edge technique.
Preface
A BRIEF OVERVIEW OF THE MECHANISMS INVOLVED IN ELECTROSPRAY MASS SPECTROMETRY
Introduction
Production of Gas-Phase Ions by Electrospray and Electrospray Ionization Mass Spectrometry
HISTORICAL PERSPECTIVES IN THE STUDY OF ION CHEMISTRY BY MASS SPECTROMETRY: FROM THE GAS PHASE TO SOLUTION
A Brief History and Recent Advances in Mass Spectrometry
Overview of the Study of Ion/Molecule Reactions in the Gas Phase by Mass Spectrometry
Future Perspectives
ORGANIC REACTION STUDIES BY ESI-MS
Introduction
Reaction Mechanisms
General Remarks
STUDIES OF REACTION MECHANISM INTERMEDIATES BY ESI-MS
Introduction
Studies on the Intermediates and Mechanisms of Pd-Catalyzed Reactions
Studies on Some Reactive Intermediates and Mechanisms of Radical Reactions
Studies on the Intermediates and Mechanism of Organocatalysis Reactions
Studies on the Intermediates and Mechanism of Transition Metal-Catalyzed Polymerization Reactions
ON-LINE MONITORING REACTIONS BY ELECTROSPRAY IONIZATION MASS SPECTROMETRY
Introduction
Preservation of the Charge in the Transit of Ions from Solution to the Gas Phase Using the ESI Technique
Developing Methods to Study Reaction Mechanisms
Probing Reactivity of Intermediates
Conclusion
GAS PHASE LIGAND FRAGMENTATION TO UNMASK REACTIVE METALLIC SPECIES
Introduction and Scope of the Review
Unmasking Reactive Metallic Intermediates via Collision-Induced Dissociation
Conclusions
PALLADIUM INTERMEDIATES IN SOLUTION
Introduction
ESI-MS Studies in Suzuki-Miyaura Cross-Coupling and Related Reactions
ESI-MS Studies in the Identification of Oxidative Addition Intermediates
ESI-MS Studies in Mizoroki-Heck and Related Reactions
ESI-MS Studies in Stille Cross-Coupling Reactions
ESI-MS Studies in Palladium-Catalyzed Reactions Involving Allenes
ESI-MS Studies in Palladium-Catalyzed Alkynylation Reactions
ESI-MS Studies in Palladium-Catalyzed Allylic Substitution Reactions
ESI-MS Studies in Palladium-Catalyzed Oxidation of 2-Allylphenols
ESI-MS Studies in Palladium-Catalyzed Polymerization Reactions
Conclusions
PRACTICAL INVESTIGATION OF MOLECULAR AND BIOMOLECULAR NONCOVALENT RECOGNITION PROCESSES IN SOLUTION BY ESI-MS
Introduction
Methods and Applications
Practical Aspects of Titration Analysis
Summary and Outlook
"In summary, this is a good source for researchers looking to utilize mass spectrometry for detecting reactive species in organic and organometallic reactions or for studying their mechanisms. It would be a worthwhile acquisition for libraries and individual scientists alike." (Journal of the American Chemical Society, November 2010)