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Renin Angiotensin System and the Heart

Renin Angiotensin System and the Heart

Walmor C. De Mello (Editor)

ISBN: 978-0-470-86294-0

Oct 2005

256 pages

Select type: E-Book



Recent studies have shown that the heart possesses an intrinsic renin angiotensin system that is controlled by tissue-specific parameters that are activated by biomechanical stress. This book reviews the latest information on the way in which both the plasma and cardiac renin angiotensin systems affect heart function.

It covers the cell and molecular biology of these systems, with contributions on renin synthesis, uptake and the intracellular signalling pathways. Particular insight comes from transgenic mouse models in which either mouse or human genes for various components of the renin angiotensin system are expressed. Other topics covered include wound healing as well as the trophic effects of aldosterone.

  • Contains the most recent findings on the renin angiotensin system and the heart
  • Written by an international team of distinguished scientists
  • Covers both the cellular and molecular basis of the renin angiotensin system and the clinical relevance of this research

List of Contributors.

1. Intracellular Signaling and the Cardiac Renin Angiotensin System (George W. Booz and Kenneth M. Baker).

2. Cardiac Physiology and the Renin-Angiotensin System: Lessons from Transgenic Animal Models.(Alisdair Ryding and John J. Mullins).

3. Prorenin Uptake in the Heart (A. H. Jan Danser).

4. Role of Local Renin-angiotensin Systems in Cardiac Damage (Michael Bader).

5. Cardiac Renin: De novo Synthesis and Uptake (Jörg Peters).

6. The Cardiac Renin Receptors (Geneviéve Nguyen, Céline Burckle and Benjamin Tremey).

7. Angiotensin II AT2 Receptors and Cardiac Function (Jun Suzuki, Takanori Kanazawa, Masaru Iwai and Masatsugu Horiuch).

8. The Heart; A Target for the Renin Angiotension System. Evidence of an intracrine system (Walmor C. De Mello).

9. ACE2: Its Role in the Counter-Regulatory Response to Heart Failure (Lawrence S. Zisman).

10. Wound Healing and the Tissue Renin-Angiotensin-Aldosterone System (Yao Sun and Karl T. Weber).

11. Trophic Effects of Aldosterone (Claude Delcayre, Christophe Heymes, Paul Milliez and Bernard Swynghedauw).

12. Intracellular Angiotensin and the Actions of Intracrine Hormones (Richard N. Re).

13. Angiotensin II and Myocardial Fibrosis, Clinical Implications (Begona López, Arantxa González and Javier Díez).

14. Hypertensive Heart Disease: Significance of Renin Angiotensin System (Jasmina Varagic and Edward D Frohlich).


"Recommended for the intended audience of cardiologists, nephrologists, cell and molecular biologists, physiologists, pathologists and pharmacologists as well as medical libraries." (E-STREAMS, May 2005)