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Reversal of Aging: Resetting the Pineal Clock (Fourth Stromboli Conference on Aging and Cancer), Volume 1057



Reversal of Aging: Resetting the Pineal Clock (Fourth Stromboli Conference on Aging and Cancer), Volume 1057

Walter Pierpaoli (Editor)

ISBN: 978-1-573-31603-3 December 2005 Wiley-Blackwell 600 Pages

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The body of research on the process of human aging has grown considerably in recent years, and the reports presented here explore a full range of approaches to this research, from the molecular and genetic to the cellular and organismic levels.

The contributing scientists identify the processes of aging and find functional and mechanistic approaches that may delay, prevent, or arrest the progress of aging and those ailments generally linked to senescence, such as metabolic, cardiovascular, and autoimmune diseases. The investigation of various approaches to the prevention of aging will include efforts to mitigate the deleterious consequences of chemical pollution.

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Introduction: The Rotational Origin and State of the Whole: Its Relation to Growth, Fertility, Aging, Death, and Diseases: Walter Pierpaoli.

Part I: The Earthly Cage of Aging: Can We Escape from It? Theories, Concepts, Views, Proposals:.

1. Multiple Longevity Phenotypes and the Transition from Health to Senescence: Robert Arking.

2. From Molecular Biology to Anti-aging Cognitive-Behavioral Practices: The Pioneering Research of Walter Pierpaoli on the Pineal and Bone Marrow Foreshadows the Contemporary Revolution in Stem Cell and Regenerative Biology: W C Bushell.

3. Genetic Contribution to Aging: Deleterious and Helpful Genes Define Life Expectancy: J I Lao, C Montoriol, I Morer, and K Beyer.

4. The Nitric Oxide Theory of Aging Revisited: S M. McCann, C Mastronardi, A De Laurentiis, and V Rettori.

5. Immunoregulation of Cellular Life Span: Marguerite Kay.

6. Lunasensor, Infradian Rhythms, Telomeres, and the Chronomere Program of Aging: Alexey Olovnikov.

7. The Pineal Aging and Death Program: Life Prolongation in Pre-aging Pinealectomized Mice: Walter Pierpaoli and Daniele Bulian.

8. Aging as a Mitochondria-Mediated Atavistic Program: Can Aging Be Switched Off?: Vladimir P. Skulachev and Valter D. Longo.

9. The Myth and Reality of Reversal of Aging by Hormesis: Joan Smith Sonneborn.

Part II: Molecular, Cellular, and Organistic Mechanisms of Aging: Suggestions, Proposals, Experimental and Clinical Evidence:.

10. Protein Kinase C Signal Transduction Regulation in Physiological and Pathological Aging: Fiorenzo Battaini and Alessia Pascale.

11. Protection of Proteins from Oxidative Stress: A New Illusion or a Novel Strategy?: Alexander A. Boldyrev.

12. The Role of Hsp70 in Age-Related Diseases and the Prevention of Cancer: Ezra V. Pierpaoli.

Part III: Biomolecular Interventions Suitable for Interpreting, Preventing, or Curing Aging:.

13. Central and Peripheral Effects of Insulin/IGF-1 Signaling in Aging and Cancer: Antidiabetic Drugs as Geroprotectors and Anticarcinogens: Vladimir N. Anisimov, Lev M. Berstein, Irina G. Popovich, Mark A. Zabezhinski, Peter A. Egormin, Margarita L. Tyndyk, Ivan V. Anikin, Anna V. Semenchenko, and Anatoli I. Yashin.

14. The Phenomenon of the Switching of Estrogen Effects and Joker Function of Glucose: Similarities and Relation to Age-Associated Pathology and Approaches to Correction: Lev M. Berstein, Evgenia V. Tsyrlina, Dmitry A. Vasilyev, Tatjana E. Poroshina, and Rina G. Kovalenko.

15. Immunomodulation by Immunopeptides and Autoantibodies in Aging, Autoimmunity, and Infection: J J Marchalonis, S F Schluter, R T Sepulveda, R R Watson, and D F Larson.

Part IV: Aging and Regeneration of the Central and Peripheral Nervous Systems—Mechanisms and Interventions: Preventative and Regenerative Medicine and Bioengineering Interventions:.

16. Age at Onset: An Essential Variable for the Definition of Genetic Risk Factors for Sporadic Alzheimer's Disease: Katrin Beyer, José I. Lao, Pilar Latorre, and Aurelio Ariza.

17. The Neuronal and Immune Memory Systems as Supervisors of Neural Plasticity and Aging of the Brain: From Phenomenology to Coding of Information: Katica D. Jovanova-Nesic And Branislav D. Jankovic.

18. Hormones Are Key Actors in Gene X Environment Interactions Programming the Vulnerability to Parkinson's Disease: Glia as a Common Final Pathway: Bianca Marchetti, Pier Andrea Serra, Francesca L'episcopo, Cataldo Tirolo, Salvo Caniglia, Nuccio Testa, Serena Cioni, Florinda Gennuso, Gaia Rocchitta, Maria Speranza Desole, Maria Clorinda Mazzarino, Egidio Miele, and Maria Concetta Morale.

19. Neurodegenerative Diseases: A Common Etiology and a Common Therapy: Walter Pierpaoli.

Part V: The Pineal Life Clock—Experimental and Clinical Activities of Melatonin: Significance and Perspectives:.

20. Clinical Perspectives for the Use of Melatonin as a Chronobiotic and Cytoprotective Agent: Daniel P. Cardinali, Analía M. Furio, and María P. Reyes.

21. Melatonin Influences on the Neuroendocrine-Reproductive Axis.

22. Beatriz Díaz López, E Díaz Rodríguez, Colmenero Urquijo, and C Fernández Álvarez.

23. Caloric Restriction Mimetics: The Next Phase: George S. Roth, Mark A. Lane, and Donald K. Ingram.

24. Mechanisms Regulating Melatonin Synthesis in the Mammalian Pineal Organ: Christof Schomerus and Horst-Werner Korf.

25. Effects of Melatonin in Age-Related Macular Degeneration: Changxian Yi, Xiaoyan Pan, Hong Yan, Mengxiang Guo, And Walter Pierpaoli.

26. Effects of Melatonin in Perimenopausal and Menopausal Women: Our Personal Experience: G Bellipanni, F Di Marzo, F Blasi, and A Di Marzo.

27. Modulatory Factors of Circadian Phagocytic Activity: Monica L. Hriscu.

28. The Role of NF-B in Protein Breakdown in Immobilization, Aging, and Exercise: From Basic Processes to Promotion of Health: Marina Bar-Shai, Eli Carmeli, and Abraham Z. Reznick.

Part VI: Replacement Therapies of a Failing Body: Clinical Evidence of Restorative Medicine:.

29. The "Multiple Hormone Deficiency" Theory of Aging: Is Human Senescence Caused Mainly by Multiple Hormone Deficiencies?: T Hertoghe.

30. Stress-Induced Hypocortisolemia Diagnosed as Psychiatric Disorders Responsive to Hydrocortisone Replacement: Suzie E. Schuder.

31. Use of Telomerase to Create Bioengineered Tissues: Jerry W. Shay and Woodring E. Wright.

32. Mind-Body Medicine: Stress and Its Impact on Overall Health and Longevity: L Vitetta, B Anton, F Cortizo, and A Sali.

33. Bio-Identical Steroid Hormone Replacement: Selected Observations from 23 Years of Clinical and Laboratory Practice: Jonathan V. Wright.

Part VII: Striving for Health—Anti-aging Medicine and Its Presence in the World: The Witnesses and Pioneers of a Rapidly Changing and Aging Western Population:.

34. Can We Delay Aging? The Biology and Science of Aging: B Anton, L Vitetta, F Cortizo, and A Sali.

35. New Horizons for the Clinical Specialty of Anti-aging Medicine: The Future with Biomedical Technologies: Ronald Klatz.

36. The Need for Anti-aging Medicine: The Challenges Faced to Incorporate Preventative Medicine into the Clinic and into Society: Philip Micans.

37. Science Is a Never-Ending Quest: A Brief Critique and Appreciation of Stromboli IV: Novera "Herb" Spector