Skip to main content

Ribosome-inactivating Proteins: Ricin and Related Proteins



Ribosome-inactivating Proteins: Ricin and Related Proteins

Fiorenzo Stirpe (Editor), Douglas Lappi (Editor)

ISBN: 978-1-118-84701-5 April 2014 Wiley-Blackwell 328 Pages


This important reference provides up-to-date information on all aspects of ribosome-inactivating proteins (RIPs). Including a list of all known RIPs, their distribution in nature, structure, genetics and chemical and immunological properties, this reference covers mechanisms of action, including the enzymatic activity on various polynucleotide substrates; the interaction with, and entry into cells; the toxicity to animals, including the pathology of poisoning; and the immunomodulatory and allergenic activity. The book further emphasizes the use of immunotoxins and other conjugates in clinical trials for the therapy of cancer and intractable pain.

Contributors vii

Preface xi

1 Introduction and History 1
Fiorenzo Stirpe

2 Occurrence and Taxonomical Distribution of Ribosome-inactivating Proteins Belonging to the Ricin/Shiga Toxin Superfamily 11
Chenjing Shang, Willy J. Peumans, and Els J. M. Van Damme

3 Ribosome-inactivating Proteins from Phytolaccaceae 28
Augusto Parente, Angela Chambery, Antimo Di Maro, Rosita Russo, and Valeria Severino

4 Ribosome-inactivating Proteins in Caryophyllaceae, Cucurbitaceae, and Euphorbiaceae 44
Tzi Bun Ng and Jack Ho Wong

5 Non-toxic Type 2 Ribosome-inactivating Proteins 67
Pilar Jiménez, Manuel José Gayoso, and Tomás Girbés

6 The Intracellular Journey of Type 2 Ribosome-inactivating Proteins 83
Robert A. Spooner and J. Michael Lord

7 Shiga Toxins: The Ribosome-inactivating Proteins from Pathogenic Bacteria 97
Maurizio Brigotti

8 The Structure and Action of Ribosome-inactivating Proteins 111
Jon D. Robertus and Arthur F. Monzingo

9 Updated Model of the Molecular Evolution of RIP Genes 134
Willy J Peumans, Chenjing Shang, and Els J. M. Van Damme

10 Enzymology of the Ribosome-inactivating Proteins 151
Yaeta Endo

11 A Long Journey to the Cytosol: What do We Know about Entry of Type 1 RIPs Inside a Mammalian Cell? 161
Rodolfo Ippoliti and Maria Serena Fabbrini

12 Ribosome-inactivating Proteins: Pathology from Cells to Organs 178
Gareth D. Griffiths

13 Antiviral and Antifungal Properties of RIPs 198
Gabriela Krivdova, Kira C. M. Neller, Bijal A. Parikh, and Katalin A. Hudak

14 Insecticidal and Antifungal Activities of Ribosome-inactivating Proteins 212
Lúcia Rosane Bertholdo Vargas and Célia Regina Carlini

15 Immunology of RIPs and their Immunotoxins 223
Giulio Fracasso and Marco Colombatti

16 Ribosome-inactivating Proteins in Cancer Treatment 244
Douglas A. Lappi and Fiorenzo Stirpe

17 Nervous System Research with RIP Conjugates: From Determination of Function to Therapy 253
Douglas A. Lappi, Jack Feldman, Dale Sengelaub, and Jill McGaughy

18 Embryotoxic and Abortifacient Activities of Ribosome-inactivating Proteins 270
Wood Yee Chan, Jack Ho Wong, and Tzi Bun Ng

19 The Potential for Misuse of Ribosome-inactivating Proteins 281
Gareth D. Griffiths

Index 287

Color plates appear between pages 116 and 117