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Signal Transduction and Human Disease

Signal Transduction and Human Disease

Toren Finkel (Editor), J. Silvio Gutkind (Editor)

ISBN: 978-0-471-44837-2

Jul 2003

488 pages



This book uniquely relates the broad impact of signal transduction research on the understanding and treatment of human disease. There have been significant advances in the area of signaling in disease processes, yet no resource presently connects these advances with understanding of disease processes and applications for novel therapeutics. Given the emphasis on translational research and biological relevance in biotechnology, and, conversely, the importance of molecular approaches for clinical research, it is evident that a single resource bridging signaling research and human disease will be invaluable.



1. Atherosclerosis: Signal Transduction by Oxygen and Nitrogen Radicals (Jonathan M. Hill, Ilsa I. Rovira, and Toren Finkel).

2. NF-kB:A Key Signaling Pathway in Asthma (Stewart J. Levine).

3. Molecular Mechanisms of Cancer (Akrit Sodhi, Silvia Montaner, and J. Silvio Gutkind).

4. Apoptotic Pathways in Cancer Progression and Treatment (Joya Chandra and Scott H. Kaufmann).

5. Molecular and Cellular Aspects of Insulin Resistance: Implications for Diabetes (Derek Le Roith, Michael J. Quon, and Yehiel Zick).

6. Dysfunction of G Protein-Regulated Pathways and Endocrine Diseases (William F. Simonds).

7. Bacterial Regulation of the Cytoskeleton (Jeremy W. Peck, Dora C. Stylianou, and Peter D. Burbelo).

8. Bacterial Toxins and Diarrhea (Walter A. Patton, Joel Moss, and Martha Vaughan).

9. Molecular Basis of Severe Combined Immunodeficiency: Lessons from Cytokine Signaling Pathways (Roberta Visconti, Fabio Candotti, and John J. O’Shea).

10. Mast Cell-Related Diseases: Genetics, Signaling Pathways, and Novel Therapies (Michael A. Beaven and Thomas R. Hundley).

11. Rheumatology and Signal Transduction (Keith M. Hull and Daniel L. Kastner).

12. Molecular Mechanisms of Neurodegenerative Disorders (Benjamin Wolozin).

13. Neurotrophic Signaling in Mood Disorders (Jing Du,Todd D. Gould, and Husseini K. Manji).

14. Inhibiting Signaling Pathways Through Rational Drug Design (James N.Topper and Neill A. Giese).


"The book is attractively laid out with clear, well-labeled figures and charts…" (Journal of Natural Products, March 2005)

"...the overall worth of the book is in the excellent job it does of taking readers from the etiology and management of the disease to our current understanding of the molecular mechanisms involved." (Quarterly Review of Biology, March-May 2005)

“…a successful work…serves as a short summarising overview…” (Signal Transduction, No.1 – 2, 2004)

"...appropriate for a textbook...pathways and their regulation are well explained and there are helpful tables and illustrations. The information is current and is well referenced...Finkel, Gutkind, and their coauthors have put together examples that illustrate the growing depth of understanding the roles of signal transduction in disease..." (Cell, January 9, 2004)

“...provides a sweeping look at current information derived from assessing the role of some kinases and phosphases on human conditions associated with disease...the book contains thoughtful, well-planned chapters...with extensive citations and excellent artwork...extremely valuable.” (Pharmaceutical Research, Vol. 20, No. 12, December 2003)