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Single Molecule Detection in Solution

Single Molecule Detection in Solution

Christoph Zander (Editor), Jörg Enderlein (Editor), Richard A. Keller (Editor)

ISBN: 978-3-527-60080-9

Jan 2003

320 pages

Select type: O-Book

Description

The detection of single molecules opens up new horizons in analytical chemistry, biology and medicine. This discipline, which belongs to the expanding field of nanoscience, has been rapidly emerging over the last ten years.
This handbook provides a thorough overview of the field. It begins with basics of single molecule detection in solution, describes methods and devices (fluorescense correlation spectroscopy, surface enhanced Raman scattering, sensors, especially dyes, screening techniques, especially confocal laser scanning microscopy). In the second part, various applications in life sciences and medicine provide the latest research results.
This modern handbook is a highly accessible reference for a broad community from advanced researchers, specialists and company professionals in physics, spectroscopy, biotechnology, analytical chemistry, and medicine. Written by leading authorities in the field, it is timely and fills a gap - up to now there exists no handbook concerning this theme.
INTRODUCTION
Theoretical Foundations of Single Molecule Detection in Solution
METHODS OF SINGLE MOLECULE DETECTION
Conceptual Basis of Fluorescence Correlation Spectroscopy and Related Techniques as Tools in Bioscience
Surface-enhanced Raman scattering (SERS) - a tool for single molecule detection in solution
Single molecule detection on surfaces with the confocal laser scanning microscope
APPLICATIONS OF SINGLE MOLECULE DETECTION
Spectroscopy of Individual Photosynthetic Pigment Protein Complexes
Single Dye Tracing for Ultrasensitive Microscopy on Living Cells
Single Molecule Identification in Solution: Principles and Applications
Studying molecular motors on single molecule level
The chemistry of a single enzyme molecule
Single Molecule Detection of Specific Nucleic Acid Sequences
Single Molecule Detection in the Near-Infrared