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Skin Lymphoma: The Illustrated Guide, 4th Edition



Skin Lymphoma: The Illustrated Guide, 4th Edition

Lorenzo Cerroni

ISBN: 978-1-118-49252-9 April 2014 Wiley-Blackwell 440 Pages

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Skin lymphomas are relatively rare but potentially fatal

They can easily be misdiagnosed as benign skin diseases. Dermatologists and pathologists need to have a good understanding of the clinical presentations and the pathological correlates of this challenging disease to ensure the correct diagnosis and most appropriate treatment is provided.


Skin Lymphoma: The Illustrated Guide is a full-color illustrated text and atlas that combines pathology with clinical features and treatment. Jam-packed with pictures that illustrate key diagnostic points and supplemented by teaching cases to highlight effective decision making. It includes all newly identified entities and provides pointers on how to differentiate these. In addition, it also covers all inflammatory conditions that may simulate skin lymphomas (cutaneous pseudolymphomas).


Skin Lymphoma: The Illustrated Guide provides


  • Clinical and pathological guidance on diagnosis of skin lymphomas
  • Clear illustrations to aid visual recognition
  • Nomenclature according to WHO/EORTC classifications
  • Cases to enhance the scope for teaching and learning


This fully refreshed fourth edition continues to provide the clinical excellence that has helped a generation of dermatologists and dermatopathologists to effectively diagnose skin lymphoma.


List of teaching cases, vii

Preface, ix

Acknowledgments, xi

1 Introduction, 1

Section 1: Cutaneous NK/T-cell lymphomas

2 Mycosis fungoides, 11

3 Sézary syndrome, 74

4 Primary cutaneous CD30+ lymphoproliferative disorders, 85

Lymphomatoid Papulosis, 86

Cutaneous Anaplastic Large Cell Lymphoma, 99

“Borderline” Cases, 109

5 Subcutaneous panniculitis-like T-cell lymphoma, 120

6 Aggressive cutaneous cytotoxic lymphomas, 133

Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-cell Lymphoma, 134

Primary Cutaneous γ/δ T-cell Lymphoma, 137

Cutaneous Extranodal NK/T-cell Lymphoma, Nasal Type, 143

7 Cutaneous peripheral T-cell lymphoma, not otherwise specifi ed (NOS), 155

8 Cutaneous CD4+ small–medium T-cell lymphoma, 163

Indolent CD8+ Lymphoid Proliferation of the Ear (Face), 166

Primary Cutaneous T-follicular helper (TFH)-cell Lymphoma, 167

9 Cutaneous adult T-cell leukemia/lymphoma, 172

10 Other cutaneous NK/T-cell lymphomas, 176

Angioimmunoblastic T-cell Lymphoma, 176

Hydroa Vacciniforme-Like Lymphoma, 179

Section 2: Cutaneous B-cell lymphomas

11 Cutaneous follicle center lymphoma, 185

12 Cutaneous marginal zone lymphoma (cutaneous MALT-lymphoma) and variants, 201

Cutaneous Marginal Zone Lymphoma, Conventional Variant, 202

Cutaneous Marginal Zone Lymphoma, Lymphoplasmacytic Variant, 208

Cutaneous Marginal Zone Lymphoma, Plasmacytic Variant, 212

Cutaneous Marginal Zone Lymphoma, Blastoid Variant, 213

13 Cutaneous diff use large B-cell lymphoma, leg type, 220

14 Intravascular large cell lymphomas, 232

Intravascular Large B-cell Lymphoma, 232

Intravascular Large NK/T-cell Lymphoma, 237

Intralymphatic CD30+ Large T-cell Lymphoma, 239

15 Other cutaneous B-cell lymphomas, 245

Cutaneous EBV+ Diff use Large B-cell Lymphoma of the Elderly, 245

Specific Cutaneous Manifestations in Mantle Cell Lymphoma, 247

Specific Cutaneous Manifestations in Extracavitary Primary Effusion Lymphoma, 248

Specific Cutaneous Manifestations in Multiple Myeloma, 250

Specific Cutaneous Manifestations in Burkitt Lymphoma, 252

Cutaneous Lymphomatoid Granulomatosis, 253

Cutaneous Plasmablastic Lymphoma, 256

Cutaneous T-cell/Histiocyte-rich B-cell Lymphoma, 258

Section 3: Cutaneous lymphomas in immunosuppressed individuals

16 Cutaneous post-transplant lymphoproliferative disorders, 265

17 Cutaneous lymphomas in HIV-infected individuals, 275

18 Cutaneous lymphoproliferative disorders in other iatrogenic and non-iatrogenic immune deficiencies, 281

Section 4: Specific cutaneous manifestations of leukemias and of precursor hematologic neoplasms

19 Cutaneous manifestations of B-cell chronic lymphocytic leukemia, 287

20 Cutaneous manifestations of myelogenous leukemia, 296

21 Blastic plasmacytoid dendritic cell neoplasm, 306

22 Cutaneous manifestations of other leukemias, 317

T-cell Prolymphocytic Leukemia, 317

Aggressive Natural Killer Cell Leukemia, 318

Specific Skin Manifestations of other Types of Leukemia, 319

23 Cutaneous lymphoblastic lymphomas, 320

Cutaneous B-lymphoblastic Lymphoma, 320

Cutaneous T-lymphoblastic Lymphoma, 323

Section 5: Cutaneous manifestations of Hodgkin lymphoma

24 Cutaneous manifestations of Hodgkin lymphoma, 331

Section 6: Cutaneous lymphomas in children and adolescents

25 Cutaneous lymphomas in children and adolescents, 341

Section 7: Pseudolymphomas of the skin

26 Pseudolymphomas of the skin, 351

Actinic reticuloid, 353

Lymphomatoid contact dermatitis, 354

Solitary idiopathic B/T-cell pseudolymphoma, 355

Lichenoid (lymphomatoid) keratosis, 357

Lichen aureus/lichenoid pigmented purpuric dermatitis, 357

Lichen sclerosus, 359

Vitiligo, 360

Annular lichenoid dermatitis of youth, 361

Pseudolymphomatous acrodermatitis chronica atrophicans, 361

Pseudolymphomatous atopic dermatitis, 362

Non-neoplastic erythroderma in adult patients, 363

Pseudolymphomatous cutaneous infiltrates in human immunodeficiency virus (HIV)-infected patients and in other immune deficiencies, 367

CD30+ T-cell pseudolymphomas, 367

Persistent nodular arthropod bite reactions and nodular scabies, 369

Pseudolymphomas in herpes simplex and herpes zoster infections, 371

Epstein–Barr virus (EBV)-associated mucocutaneous ulcers, 372

Hydroa vacciniforme, 373

Pityriasis lichenoides, 374

Pseudolymphomas associated with lupus erythematosus, 376

Lymphomatoid drug reactions, 379

Lymphocytoma cutis, 380

Pseudolymphomas at sites of vaccination, 384

Pseudolymphomas in tattoos, 385

Localized scleroderma/morphea, 386

Cutaneous IgG4-related disease, 386

Pseudolymphomas in syphilis, 386

Cutaneous plasma cell granuloma, 388

Cutaneous and systemic plasmacytosis, 389

Cutaneous manifestations of Castleman disease, 392

Pre-tibial lymphoplasmacytic plaque in children, 393

Cutaneous extramedullary hematopoiesis, 394

Histiocytoid Sweet syndrome, 395

Intralymphatic histiocytosis, 396

Benign intralymphatic proliferation of T-cell lymphoid blasts, 397

Other “accidental” pseudolymphomas, 398

“Malignant” pseudolymphomas, 399

Section 8: The cutaneous “atypical lymphoid proliferation”

27 The cutaneous “atypical lymphoid proliferation”, 413

Index, 415

“This comprehensive illustrated book provides a superb guide to a rare and complex disease.”  (Cancer Nursing Practice, 1 October 2014)