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Somatostatin and Its Receptors

Somatostatin and Its Receptors

Derek J. Chadwick (Editor), Gail Cardew (Editor)

ISBN: 978-0-470-51474-0 April 2008 284 Pages




This book describes a diverse analysis of the five somatostatin receptors; somatostatin gene regulation; promatostatin processing; mechanisms of signal transduction; and the design and use of somatostatin analogues, including their possible clinical implications. The book will provide a comprehensive summary of the cellular and molecular biology of somatostatin and its recently isolated receptors. The book will review the design and use of specific somatostatin analogues both biochemically to characterize the specific functions of somatostatin and clinically in the treatment of various tumors.
Partial table of contents:

Regulation of Somatostatin Gene Transcription by cAMP (M. Montminy, et al.).

Processing and Intracellular Targeting of Prosomatostatin-Derived Peptides: The Role of Mammalian Endoproteases (Y. Patel & A. Galanopoulou).

Molecular Biology of Somatostatin Receptors (G. Bell, et al.).

Characterization of Somatostatin Receptor Subtypes (Ch.

Bruns, et al.).

Regulation of Somatostatin Receptor mRNA Expression (M. Berelowitz, et al.).

Transient Expression of Somatostatin Receptors in the Brain During Development (P. Leroux, et al.).

Interaction of Somatostatin Receptors with G Proteins and Cellular Effector Systems (T. Reisine, et al.).

Function and Regulation of Somatostatin Receptor Subtypes (A. Schonbrunn, et al.).