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Systems Biology in Practice: Concepts, Implementation and Application



Systems Biology in Practice: Concepts, Implementation and Application

Edda Klipp, Ralf Herwig, Axel Kowald, Christoph Wierling, Hans Lehrach

ISBN: 978-3-527-60488-3 July 2008 Wiley-Blackwell 486 Pages


Presenting the main concepts, this book leads students as well as advanced researchers from different disciplines to an understanding of current ideas in the complex field of comprehensive experimental investigation of biological objects, analysis of data, development of models, simulation, and hypothesis generation.
It provides readers with guidance on how a specific complex biological question may be tackled:
- How to formulate questions that can be answered
- Which experiments to perform
- Where to find information in databases and on the Internet
- What kinds of models are appropriate
- How to use simulation tools
- What can be learned from the comparison of experimental data and modeling results
- How to make testable predictions.
The authors demonstrate how mathematical concepts can illuminate the principles underlying biology at a genetic, molecular, cellular and even organism level, and how to use mathematical tools for analysis and prediction.


Part I: General Introduction.

1. Basic Principles.

2. Biology in a Nutshell.

3. Mathematics in a Nutshell.

4. Experimental Techniques in a Nutshell.

Part II: Standard Models and Approaches in Systems Biology.

5. Metabolism.

6. Signal Transduction.

7. Selected Biological Processes.

8. Modeling of Gene Expression.

9. Analysis of Gene Expression Data.

10. Evolution and Self-organization.

11. Data Integration.

12. What’s Next?

Part III: Computer-based Information Retrieval and Examination.

13. Databases and Tools on the Internet.

14. Modeling Tools.

Subject Index.

"...this is one book that I bought for myself as soon as it was published." (British Journal of Occupational Therapy, February 2008)

"This resource does an admirable job of bringing the readers to a level where they can pursue more advanced study and research." (IEEE Engineering in Medicine and Biology Magazine, January/February 2008)

"This rapid survey of a developing field is ideal for beginning graduate students…" (CHOICE, December 2005)

"This is a timely volume that should be welcomed both by practising systems biologists and by newcomers to the field.... I expect to consult it regularly over the foreseeable future, and I am confident that biologists everywhere will benefit from having a copy to hand." (Theoretical Biology and Medical Modelling)

"The authors manage to cover an astoundingly wide range of topics and to present the great potential of systems biology to the reader. The first introductory part makes it an ideal book for researchers from neighbouring disciplines, who benefit from the compact and clearly written basics in biology and mathematics. But the main area of application will be as textbook for the growing number of students interested in bioinformatics, systems biology and theoretical biology. With its 14 chapters, 450 pages and many diagrams and examples it provides plenty of material for lecturing." (Arzneimittel-Forschung/Drug Research)