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Target Discovery and Validation

Target Discovery and Validation

Alleyn T. Plowright, Raimund Mannhold, Helmut Buschmann, Jörg Holenz

ISBN: 978-3-527-81825-9

Feb 2020

416 pages

$172.99

Product not available for purchase

Description

Current methods for the identification and validation of drug targets from one handy reference - complete with case studies and numerous practical examples.
Introduction to target discovery and target validation

PART 1: BIOCHEMICAL-BASED APPROACHES
Targeted/annotated libraries and target profiling for target discovery
Affinity-based methods using chemoproteomics for target identification
Activity based protein profiling
Kinobeads type approach
Label-free techniques for target discovery and validation
Chemical strategies for target validation

PART 2: BIOLOGY-BASED APPROACHES
Cell biology techniques for target validation
Understanding the broader phenotype
Gene manipulation/modulation
Yeast three hybrid system

PART 3: INFORMATICS-BASED APPROACHES
Computational Approaches for target inference
Bioinformatics approaches
Investigating the broader phenotype of a compound

PART 4: CASE STUDIES
Case study 1
Case study 2
Case study 3

Conclusions