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The HPLC Solvent Guide, 2nd Edition

The HPLC Solvent Guide, 2nd Edition

Paul C. Sadek

ISBN: 978-0-471-41138-3

Feb 2002

664 pages

Select type: Hardcover

In Stock



High-performance liquid chromatography (HPLC) is a procedure for separating components from a mixture of chemical substances; a combination of separation, identification, and quantitative measurements. Solvent selection is perhaps the most commonly overlooked parameter in HPLC. Even the most experienced analytical chemist tends to select one of three familiar solvents. The HPLC Solvent Guide provides detailed coverage of all commonly used HPLC solvents used in a wide range of separations.

HPLC is a mature but substantial market, and one that Wiley reaches successfully and well. The HPLC list is established, and this second edition of a successful title will build upon the success of the first. This is a revised and expanded edition in a field that is still growing into areas of analysis and methods.



Abbreviations, Acronyms, and Symbols.

Chapter 1: Physical and Chemical Solvent Properties.

Chapter 2: Method Optimization.

Chapter 3: Method Validation and Ongoing Performance Evaluation.

Chapter 4: Alcohols.

Chapter 5: Alkanes and Alkyl Aromatics.

Chapter 6: Chlorinated Alkanes and Chlorinated Benzenes.

Chapter 7: Ethers.

Chapter 8: Keotones and Esters.

Chapter 9: Nitriles and Nitrogenous Solvents.

Chapter 10: Water, Dimethyl Sulfoxide, and Common Acidic Modifiers.


"...a convenient handbook to anyone wishing to improve his of her ability to develop and implement successful HPLC applications..." (Analytical and Bioanalytical Chemistry, Vol 378(1), Jan 2004)

"...offers practical and operational information about solvents for use in high-pressure liquid chromatography." (Journal of the American Chemical Society, Vol. 124, No. 35, 2002)

"...describes all of the commonly used HLPC solvents." (SciTech Book News, Vol. 26, No. 2, June 2002)

"...a convenient handbook for anyone wishing to improve his or her ability to develop and implement successful HPLC applications." (Annals of Bioanalytical Chemistry, Vol. 378)