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The HPLC Solvent Guide, 2nd Edition



The HPLC Solvent Guide, 2nd Edition

Paul C. Sadek

ISBN: 978-0-471-41138-3 February 2002 664 Pages


High-performance liquid chromatography (HPLC) is a procedure for separating components from a mixture of chemical substances; a combination of separation, identification, and quantitative measurements. Solvent selection is perhaps the most commonly overlooked parameter in HPLC. Even the most experienced analytical chemist tends to select one of three familiar solvents. The HPLC Solvent Guide provides detailed coverage of all commonly used HPLC solvents used in a wide range of separations.
HPLC is a mature but substantial market, and one that Wiley reaches successfully and well. The HPLC list is established, and this second edition of a successful title will build upon the success of the first. This is a revised and expanded edition in a field that is still growing into areas of analysis and methods.


Abbreviations, Acronyms, and Symbols.

Chapter 1: Physical and Chemical Solvent Properties.

Chapter 2: Method Optimization.

Chapter 3: Method Validation and Ongoing Performance Evaluation.

Chapter 4: Alcohols.

Chapter 5: Alkanes and Alkyl Aromatics.

Chapter 6: Chlorinated Alkanes and Chlorinated Benzenes.

Chapter 7: Ethers.

Chapter 8: Keotones and Esters.

Chapter 9: Nitriles and Nitrogenous Solvents.

Chapter 10: Water, Dimethyl Sulfoxide, and Common Acidic Modifiers.


"...a convenient handbook for anyone wishing to improve his or her ability to develop and implement successful HPLC applications."
Annals of Bioanalytical Chemistry
Vol. 378

"...still a very serious and comprehensive book on the statistical theory of multivariate analysis."
Vol. 46, No. 1, February 2004