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Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives

Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives

Roland Kontermann (Editor)

ISBN: 978-3-527-64482-7

Feb 2012, Wiley-Blackwell

372 pages

Description

For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.
GENERAL INFORMATION
Half-life modulating strategies - an introduction (Roland Kontermann)

Pharmacokinetics and half-life protein of therapeutics (Bernd Meibohm)

HALF-LIFE EXTENSION THROUGH CHEMICAL AND POSTTRANSLATIONAL MODIFICATIONS
Half-life extension through PEGylation (Simona Jevsevar and Menci Kunstelj)

Half-life extension of therapeutic proteins via genetic fusion to recombinant PEG mimetics
(Uli Binder and Arne Skerra)

Half-life extension through O-glyosylation (Fuad Fares)

Polysialic acid and polysialylation to modulate antibody pharmacokinetics (Antony Constantinou, Chen Chen and Mahendra P. Deonarain)

Half-life extension through HESylation (Thomas Hey, Helmut Knoller and Peter Vorstheim)

HALF-LIFE MODULATION INVOLVING RECYCLING BY THE NEONATAL FC RECEPTOR
The biology of FcRn (Jonghan Kim)

Half-life extension by fusion to the Fc region (Jalal A. Jazayeri and Graeme J Carroll)

Monomeric Fc fusion Technology: an approach to create long lasting clotting factors (Jennifer A. Dumont, Xiaomei Jei, Robert T. Peters, Alvin Luk, Glenn F. Pierce and Alan J. Bitonti)

The diverse roles of FcRn: implications for antibody engineering (Sally Ward and Raimund J. Ober)

Half-life extension by fusion to albumin (Hubert J. Metzner, Thomas Weimer and Stefan Schulte)

AlbudAb(TM) technology platform: versatile albumin binding domains for the development of therapeutics with tunable half-lives (Christopher Herring and Oliver Schon)

Half-life extension by binding to albumin through an albumin-binding domain (Fredrik Frejd)

Half-life extension by binding to albumin through small molecules (Sabrina Trüssel, Joerg Scheuermann and Dario Neri)

HALF-LIFE EXTENSION WITH PHARMACEUTICAL FORMULATIONS
Half-life extension with pharmaceutical formulations: liposomes (Astrid Hartung and Gerd Bendas)

Half-life extension with pharmaceutical formulations: nanoparticles (Katharina Landfester)
"The majority of future protein therapeutics will be modified in one way or another using techniques and concepts described in this monograph. Therefore it can be safely stated that this is an extremely relevant contribution, which should be on hand for all those who think about or work on protein therapeutics." (Biotechnology Journal, Nov 2012)