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Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, 2 Volume Set, 5th Edition

Thomas' Hematopoietic Cell Transplantation: Stem Cell Transplantation, 2 Volume Set, 5th Edition

Stephen J. Forman (Editor), Robert S. Negrin (Editor), Joseph H. Antin (Editor), Frederick R. Appelbaum (Editor)

ISBN: 978-1-118-41642-6

Jan 2016, Wiley-Blackwell

1416 pages


Fully revised for the fifth edition, this outstanding reference on bone marrow transplantation is an essential, field-leading resource.
  • Extensive coverage of the field, from the scientific basis for stem-cell transplantation to the future direction of research
  • Combines the knowledge and expertise of over 170 international specialists across 106 chapters
  • Includes new chapters addressing basic science experiments in stem-cell biology, immunology, and tolerance
  • Contains expanded content on the benefits and challenges of transplantation, and analysis of the impact of new therapies to help clinical decision-making
  • Includes a fully searchable Wiley Digital Edition with downloadable figures, linked references, and more
  • References for this new edition are online only, accessible via the Wiley Digital Edition code printed inside the front cover or at

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Contributors, xi

Preface to the First Edition, xvii

Preface to the Fifth Edition, xviii

Tribute, xix

List of Abbreviations, xxii

Section 1: History and Use of Hematopoietic Cell Transplantation

1 A History of Allogeneic and Autologous Hematopoietic Cell Transplantation, 1
Karl G. Blume and E. Donnall Thomas

2 Uses and Growth of Hematopoietic Cell Transplantation, 8
Mary M. Horowitz

Section 2: Scientific Basis or Hematopoietic Cell Transplantation

Section 2a: Hematopoiesis and Stem Biology Transplantation

3 Generation of Definitive Engraftable Hematopoietic Stem Cells from Human Pluripotent Stem Cells, 16
Laurence Dahéron and David T. Scadden

4 Hematopoietic Stem Cells, Regenerative Medicine, and Leukemogenesis, 25
Irving Weissman

5 Marrow Microenvironment and Biology of Mobilization of Stem Cells, 50
Michael P. Rettig, Mark A. Schroeder and John F. DiPersio

6 Expansion of Human Hematopoietic Stem Cells, 62
Colleen Delaney

7 Mesenchymal Stromal Cells and Hematopoietic Cell Transplantation, 69
Edwin M. Horwitz

8 Genetic Manipulation of Hematopoietic Stem Cells, 78
Jennifer E. Adair, Grant D. Trobridge and Hans-Peter Kiem

Section 2b: Immunology

9 Overview of Hematopoietic Cell Transplantation Immunology, 96
Paul J. Martin and Warren D. Shlomchik

10 Histocompatibility, 112
Effie W. Petersdorf

11 Natural Killer Cells and Allogeneic Hematopoietic Cell Transplantation, 126
Michael R. Verneris and Jeffrey S. Miller

12 Mechanisms of Tolerance, 136
Defu Zeng and Samuel Strober

13 The Pathophysiology of Graft-versus-Host Disease, 146
James L.M. Ferrara and Joseph H. Antin

14 Immune Regulation in Hematopoietic Cell Transplantation, 153
Robert S. Negrin and Jerome Ritz

15 Immune Reconstitution Following Hematopoietic Cell Transplantation, 160
Jarrod A. Dudakov, Miguel-Angel Perales and Marcel R.M. van den Brink

16 Biology of the Human Graft-versus-Tumor Response and How to Exploit It, 166
Edus H. Warren

17 Dendritic Cells in Hematopoietic Cell Transplantation, 178
Miriam Merad and Edgar G. Engleman

18 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases, 191
Judith A. Shizuru

Section 2c: Technical Aspects

19 Pharmacologic Basis for High-dose Chemotherapy, 211
Borje S. Andersson, Benigno C. Valdez and Roy B. Jones

20 High-dose Preparatory Regimens, 223
William I. Bensinger

21 Reduced-intensity Allogeneic Transplantation Regimens, 232
Brenda M. Sandmaier and Rainer Storb

22 Radiotherapeutic Principles of Hematopoietic Cell Transplantation, 244
Jeffrey Y.C. Wong and Timothy Schultheiss

23 Radioimmunotherapy and Hematopoietic Cell Transplantation, 258
John M. Pagel and Ajay K. Gopal

24 Documentation of Engraftment and Characterization of Chimerism After Hematopoietic Cell Transplantation, 272
Paul J. Martin

25 The Detection and Significance of Minimal Residual Disease, 281
Merav Bar and Jerald P. Radich

26 Pathology of Hematopoietic Cell Transplantation, 292
Keith R. Loeb, Cecilia C. Yeung and Howard M. Shulman

27 Biostatistical Methods in Hematopoietic Cell Transplantation, 329
Joycelynne M. Palmer and Ted A. Gooley

28 Outcomes Research in Hematopoietic Cell Transplantation, 341
Stephanie J. Lee

Section 3: Patient-oriented Issues in Hematopoietic Cell Transplantation

29 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation, 349
Bart L. Scott and Brenda M. Sandmaier

30 Nursing Role in Hematopoietic Cell Transplantation, 362
Rosemary C. Ford, Mihkaila M. Wickline and Diane Heye

31 Ethical Issues in Hematopoietic Cell Transplantation, 374
David S. Snyder

32 Psychosocial Issues in Hematopoietic Cell Transplantation, 384
Richard P. McQuellon and Katharine E. Duckworth

33 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients, 392
Karen L. Syrjala and Samantha Burns Artherholt

34 Sexuality Following Hematopoietic Cell Transplantation, 399
D. Kathryn Tierney

35 Hematopoietic Cell Transplantation: The Patient's Perspective, 407
Susan K. Stewart

Section 4: Sources of Hematopoietic Cell for Hematopoietic Cell Transplantation

36 Hematopoietic Cell Procurement, Processing, and Transplantation: Standards, Accreditation, and Regulation, 414
Phyllis I. Warkentin and Elizabeth J. Shpall

37 Bone Marrow and Peripheral Blood Cell Donors and Donor Registries, 423
Dennis L. Confer, John P. Miller and Jeffrey W. Chell

38 The Role of the Transplant Program in a Nuclear Accident or Terrorism, 431
Nelson J. Chao and Dennis L. Confer

39 Cord Blood Hematopoietic Cell Transplantation, 437
Hal E. Broxmeyer, Sherif S. Farag and Vanderson Rocha

40 Mobilization of Peripheral Blood Hematopoietic Cells for Autologous HCT, 452
Thomas C. Shea and John F. DiPersio

41 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation, 460
Norbert Schmitz and Peter Dreger

42 Cryopreservation of Hematopoietic Cells, 469
Scott D. Rowley

43 Use of Recombinant Growth Factors after Hematopoietic Cell Transplantation, 480
Jürgen Finke and Roland Mertelsmann

44 Hematopoietic Cell Transplantation from Human Leukocyte Antigen Partially Matched Related Donors, 489
Claudio Anasetti, Franco Aversa and Andrea Velardi

45 Hematopoietic Cell Transplantation from Unrelated Donors, 505
Effie W. Petersdorf

Section 5: Hematopoietic Cell Transplantation for Acquired Disease

46 Hematopoietic Cell Transplantation for Aplastic Anemia, 517
George E. Georges and Rainer Storb

47 Hematopoietic Cell Transplantation for Paroxysmal Nocturnal Hemoglobinuria, 537
Ryotaro Nakamura

48 Hematopoietic Stem Cell Transplantation for Chronic Myeloid Leukemia, 545
Jerald P. Radich and Ravi Bhatia

49 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia, 554
Charlotte M. Niemeyer and Franco Locatelli

50 Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia, 563
Frederick R. Appelbaum

51 Hematopoietic Cell Transplantation for Childhood Acute Myeloid Leukemia, 576
Michael A. Pulsipher, Meghann McManus and Soheil Meshinchi

52 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults, 588
Stephen J. Forman

53 Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Children, 600
Parinda A. Mehta and Stella M. Davies

54 Hematopoietic Cell Transplantation for Myelodysplastic Syndromes and Myeloproliferative Neoplasms, 613
H. Joachim Deeg

55 Hematopoietic Cell Transplantation for Multiple Myeloma, 625
Amrita Krishnan and Sergio A. Giralt

56 Hematopoietic Cell Transplantation for Hodgkin Disease, 636
Philip J. Bierman and Auayporn Nademanee

57 Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma (B Cell), 653
Leslie L. Popplewell and Ginna G. Laport

58 Hematopoietic Cell Transplantation for Non-Hodgkin Lymphoma (T Cell), 664
Jasmine Zain and Sandra H. Thomas

59 Hematopoietic Cell Transplantation for Chronic Lymphocytic Leukemia, 675
Aaron C. Logan and David B. Miklos

60 Autologous Hematopoietic Cell Transplantation for Systemic Light Chain (AL-) Amyloidosis, 685
Heather J. Landau, Morie A. Gertz and Raymond L. Comenzo

61 Autologous Hematopoietic Cell Transplantation for Breast Cancer and Germ-cell Tumors, 700
Yago Nieto and Elizabeth J. Shpall

62 Hematopoietic Cell Transplantation for Renal Cell Carcinoma and Other Solid Tumors, 709
Richard W. Childs and Ramaprasad Srinivasan

63 Hematopoietic Cell Transplantation for Neuroblastoma, 721
Justin T. Wahlstrom and Katherine K. Matthay

64 Hematopoietic Cell Transplantation for Other Pediatric Solid Tumors, 729
Masanori Hayashi, David M. Loeb and Allen R. Chen

65 Hematopoietic Cell Therapy for Human Immunodeficiency Virus Infection, 742
Amrita Krishnan, Joseph Alvarnas, John J. Rossi and John A. Zaia

66 Hematopoietic Cell Transplantation for Autoimmune Diseases, 753
Richard A. Nash

67 Hematopoietic Cell Transplantation for Rare Hematologic Malignancies, 765
Vinod Pullarkat and Stephen J. Forman

68 Adoptive T-cell Therapy for Viral Disease in the Setting of Hematopoietic Cell Transplantation, 777
Catherine M. Bollard and Helen E. Heslop

69 Adoptive T-cell Therapy for Malignancy in the Setting of Hematopoietic Cell Transplantation, 787
Stephen J. Forman, Michael Kalos and Carl H. June

70 Relapse of Hematologic Malignancy After Allogeneic Hematopoietic Transplantation, 797
Richard Champlin

Section 6: Hematopoietic Cell Transplantation for Inherited Disease

71 Hematopoietic Cell Transplantation for Thalassemia, 803
Guido Lucarelli and Javid Gaziev

72 Hematopoietic Cell Transplantation for Sickle Cell Disease, 814
Mark C. Walters

73 Hematopoietic Cell Transplantation for Immunodeficiency Diseases, 827
Richard J. O'Reilly and Wilhelm Friedrich

74 Hematopoietic Cell Transplantation for Storage Diseases, 846
Joseph Rosenthal

75 Hematopoietic Cell Transplantation for Macrophage, Granulocyte and Osteoclast, Disorders, 871
Rajni Agarwal

76 Hematopoietic Cell Transplantation for Fanconi Anemia, 884
John E. Wagner, Jakub Tolar, Arleen D. Auerbach and Margaret L. MacMillan

Section 7: Complications of Hematopoietic Cell Transplantation

77 Mechanisms and Treatment of Graft Failure, 905
Robert Lowsky and Hans Messner

78 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation, 916
Margaret R. O'Donnell

79 Principles of Transfusion Support Before and After Hematopoietic Cell Transplantation, 922
Jeffrey McCullough

80 Vascular Access and Complications, 937
I. Benjamin Paz

81 Pharmacologic Prevention of Acute Graft-versus-Host Disease, 951
Nelson J. Chao

82 T-cell Depletion to Prevent Graft-versus-Host Disease, 965
Robert J. Soiffer

83 Manifestations and Treatment of Acute Graft-versus-Host Disease, 973
Corey Cutler and Joseph H. Antin

84 Chronic Graft-versus-Host Disease – Clinical Manifestations and Therapy, 981
Paul A. Carpenter, Mary E.D. Flowers and Steven Z. Pavletic

85 Bacterial Infections, 999
Helen L. Leather and John R. Wingard

86 Fungal Infections After Hematopoietic Cell Transplantation, 1018
Kieren A. Marr

87 Cytomegalovirus Infection, 1030
John A. Zaia

88 Herpes Simplex Virus Infections, 1039
Sanjeet S. Dadwal and James I. Ito

89 Varicella Zoster Virus Infections, 1046
Dora Y. Ho and Ann M. Arvin

90 Epstein–Barr Virus Infection, 1066
Jennifer A. Kanakry and Richard F. Ambinder

91 Respiratory Viruses After Hematopoietic Cell Transplantation, 1073
Sachiko Seo and Michael Boeckh

92 HHV-6A, HHV-6B, HHV-7, and HHV-8 After Hematopoietic Cell Transplantation, 1083
Per Ljungman, Tetsushi Yoshikawa and Katherine N. Ward

93 Human Adenovirus, Polyomavirus, and Parvovirus Infections in Patients Undergoing Hematopoietic Stem Cell Transplantation, 1090
Hans H. Hirsch and Steven A. Pergam

94 Gastrointestinal and Hepatic Complications, 1101
David M. Hockenbery, Simone I. Strasser and George B. McDonald

95 Lung Injury Following Hematopoietic Cell Transplantation, 1117
Kenneth R. Cooke and Gregory A. Yanik

96 Kidney and Bladder Complications of Hematopoietic Cell Transplantation, 1131
Sangeeta Hingorani

97 Endocrine Complications Following Hematopoietic Cell Transplantation, 1142
Fouad R. Kandeel and Behrouz Salehian

98 Common Potential Drug Interactions Following Hematopoietic Cell Transplantation, 1167
Anne Poon and Lowan K. Ly

99 Nutrition Support of the Hematopoietic Cell Transplant Recipient, 1177
Paula Charuhas Macris and Kerry K. McMillen

100 Pain Management, 1186
Noelle V. Frey and Jonathan R. Gavrin

101 Oral Complications of Hematopoietic Cell Transplantation, 1203
Mark M. Schubert, Maria Elvira Pizzigatti Correa and Douglas E. Peterson

102 Growth and Development After Hematopoietic Cell Transplantation, 1218
K. Scott Baker and Anna Petryk

103 Delayed Non-malignant Complications After Hematopoietic Cell Transplantation, 1227
Smita Bhatia

104 Subsequent Malignant Neoplasms After Hematopoietic Cell Transplantation, 1236
Smita Bhatia and Ravi Bhatia

105 Neurologic Complications of Hematopoietic Cell Transplantation, 1248
Harry Openshaw and Bihong T. Chen

106 Vaccination of Allogeneic and Autologous Hematopoietic Cell Recipients, 1258
Trudy N. Small

Index, 1266