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Thymosins in Health and Disease I: Third International Symposium, Volume 1269



Thymosins in Health and Disease I: Third International Symposium, Volume 1269

Allan L. Goldstein (Editor), Enrico Garaci (Editor)

ISBN: 978-1-573-31871-6 November 2012 Wiley-Blackwell 252 Pages

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The first of two, this volume comprises a collection of papers devoted to the understanding of thymosins—proteins originally isolated from the thymus and possess a unique array of biological properties. Thymosins in Health and Disease I brings together short reviews organized to explore the basic characteristics of these peptides and their hormone-like properties, recent preliminary evidence for their medicinal utility, and a focus on the alpha and beta thymosin families. In particular, Thymosin β4 (Tβ4) holds considerable promise for the treatment of many conditions and diseases. Of note, contributions to this volume include information on the application of thymosins to stem cell differentiation, neurological and cardiovascular regeneration, as well as accounts of thymosins in relation to basic regulatory and cancer cell functions. 

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Introduction for Thymosins in Health and Disease vii
Allan L. Goldstein and Enrico Garaci

Thymosins: chemistry, genetics, receptors, signaling, and multifunctionality

Jack of all trades: thymosin α1 and its pleiotropy 1
Luigina Romani, Silvia Moretti, Francesca Fallarino, Silvia Bozza, Loredana Ruggeri, Andrea Casagrande, Franco Aversa, Francesco Bistoni, Andrea Velardi, and Enrico Garaci

Single-domain β-thymosins: the family history 7
John Edwards

Controlled delivery of thymosin β4 for tissue engineering and cardiac regenerative medicine 16
Loraine L. Y. Chiu, Lewis A. Reis, and Milica Radisic

Thymosin α1 and cancer: action on immune effector and tumor target cells 26
Enrico Garaci, Francesca Pica, Annalucia Serafino, Emanuela Balestrieri, Claudia Matteucci, Gabriella Moroni, Roberta Sorrentino, Manuela Zonfrillo, Pasquale Pierimarchi, and Paola Sinibaldi-Vallebona

Prothymosin α plays multifunctional cell robustness roles in genomic, epigenetic, and nongenomic mechanisms 34
Hiroshi Ueda, Hayato Matsunaga, and Sebok Kumar Halder

Thymosin β4 is rapidly internalized by cells and does not induce intracellular Ca²⁺ elevation 44
Czeslaw S. Cierniewski, Katarzyna Sobierajska, Anna Selmi, Jakub Kryczka, and Radoslaw Bednarek

Thymosins: molecular markers, wound healing, fibrosis, inflammation, and hypoxia

Thymosin β4 expression reveals intriguing similarities between fetal and cancer cells 53
Carvino Faa, Sonia Nemolato, Tiziana Cabras, Daniela Fanni, Clara Gerosa, Mattia Fanari, Annalisa Locci, Vassilios Fanos, Irene Messana, and Massimo Castagnola

Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats 61
Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Marcos Rojkind, and M. Raj Lakshman

Protective effects of thymosin β4 in a mouse model of lung fibrosis 69
Enrico Conte, Tiziana Genovese, Elisa Gili, Emanuela Esposito, Maria Iemmolo, Mary Fruciano, Evelina Fagone, Maria Provvidenza Pistorio, Nunzio Crimi, Salvatore Cuzzocrea, and Carlo Vancheri

Thymosin β4 affecting the cytoskeleton organization of the myofibroblasts 74
H. Paul Ehrlich and Sprague W. Hazard

Thymosin β4 stabilizes hypoxia-inducible factor-1α protein in an oxygen-independent manner 79
Mee Sun Ock, Kyoung Seob Song, Hynda Kleinman, and Hee-Jae Cha

Thymosin β4: cardiovascular protection, neuroplasticity and regeneration, and stem cell differentiation

Thymosin β4 and cardiac protection: implication in inflammation and fibrosis 84
Sudhiranjan Gupta, Sandeep Kumar, Nikolai Sopko, Yilu Qin, Chuanyu Wei, and Il-Kwon Kim

Myocardial regeneration: expanding the repertoire of thymosin β4 in the ischemic heart 92
Nicola Smart, Sveva Bollini, Karina D. Dubé, Joaquim M. Vieira, Bin Zhou, Johannes Riegler, Anthony N. Price, Mark F. Lythgoe, Sean Davidson, Derek Yellon, William T. Pu, and Paul R. Riley

Molecular and cellular mechanisms of thymosin β4-mediated cardioprotection 102
Rabea Hinkel, Teresa Trenkwalder, and Christian Kupatt

Treatment of neurological injury with thymosin β4 110
Daniel C. Morris, Zheng G. Zhang, Jing Zhang, Ye Xiong, Li Zhang, and Michael Chopp

Therapeutic potential of thymosin β4 in myocardial infarct and hear failure 117
Christoffer Stark, Pekka Taimen, Miikka Tarkia, Jussi Pärkkä, Antti Saraste, Tero-Pekka Alastalo, Timo Savunen, and Juha Koskenvuo

Thymosin β4 mobilizes mesothelial cells for blood vessel repair 125
Elaine L. Shelton and David M. Bader

Appendix: Historical article reprinted from Annals of the New York Academy of Sciences 332: 33-48 (1979)

Current status of thymosin research: Evidence for the existence of a family of thymic factors that control T-cell maturation 131
Teresa L. K. Low, Gary B. Thurman, Carolina Chincarini, John E. McClure, Gailen D. Marshalll, Shu-Kuang Hu, and Allan L. Goldstein