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Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Transcription Factors in the Nervous System: Development, Brain Function, and Diseases

Gerald Thiel (Editor)

ISBN: 978-3-527-60736-5

May 2006, Wiley-Blackwell

505 pages

Select type: E-Book



This first book to cover neural development, neuronal survival and function on the genetic level outlines promising approaches for novel therapeutic strategies in fighting neurodegenerative disorders, such as Alzheimer's disease. Focusing on transcription factors, the text is clearly divided into three sections devoted to transcriptional control of neural development, brain function and transcriptional dysregulation induced neurological diseases.
With a chapter written by Nobel laureate Eric Kandel, this is essential reading for neurobiologists, geneticists, biochemists, cell biologists, neurochemists and molecular biologists.
Roles of Hes bHLH Factors in Neuronal Development
The Role of Pax6 in the Nervous System During Development and in Adulthood -
Master Control Regulator or Modular Function?
Phox2a and Phox2b Essential Transcription Factors or Neuron Specification and Differentiation
Functions of LIM-Homedomain Proteins in the Development of the Nervous System
Function of SRF and Ternary Complex Factors in the Nervous System
RE-1 Silencing Transcription Factor (REST) -
Regulation of Neuronal Gene Expression Via Modification of the Chromatin Structure
Roles of Tix1 and TIX3 and Neuronal Activity in Controlling Glutamatergic Over GABAergic Cell Fates
Transcriptional Control of the Development of Central Serotoneric Neurons
Role of Nkx Homeodomain Factors in the Specification and Differentiation of Motor Neurons and Oligodendrocytes
Sox Transcription Factors in Neural Development
Role of CREB and CBP in Brain Function
CCAAT Enhancer Binding Proteins in the Nervous System: Their Role in Development, Differentiation, Long-term Synaptic Plasticity and Memory
Role of c-Jun in Brain Function
Expression, Function, and Regulation of Transcription Factor MEF2 in Neurons
RORalpha, an Orphan that Staggers the Mind
Role of NF-kappaB in Brain Function
Calcineurin/NFAT Signaling in Development and Function of the Nervous System
Stimulus-Transcription Coupling in the Nervous System -
The Zinc Finger Protein Egr-1
The Presenilin/gamma-Secretase Complex Regulates Production of Transcriptional Factors: Effects of FAD Mutations
Transcriptional Abnormalities in Huntington's Disease
""…this volume presents critical information for neuroscientists while also providing a valuable resource for biologists, chemists, and geneticists in related fields or in biomedical research."" (The Quarterly Review of Biology, December 2006)

""This is a great buy for those who deal with this matter on a daily basis."" (Doody's Health Services)