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Transporters as Drug Carriers: Structure, Function, Substrates

Transporters as Drug Carriers: Structure, Function, Substrates

Gerhard F. Ecker (Editor), Peter Chiba (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)

ISBN: 978-3-527-31661-8

Nov 2009

449 pages

In Stock

$248.00

Description

This reference handbook is the first to provide a comprehensive overview, systematically characterizing all known transporters involved in drug elimination and resistance. Combining recent knowledge on all known classes of drug carriers, from microbes to man, it begins with a look at human and mammalian transporters. This is followed by microbial, fungal and parasitic transporters with special attention given to transport across those physiological barriers relevant for drug uptake, distribution and excretion.
As a result, this key resource lays the foundations for understanding and investigating the molecular mechanisms for multidrug resistance in cancer cells, microbial resistance to antibiotics and pharmacokinetics in general.
For anyone working with antibiotics and cancer chemotherapeutics, as well as being of prime interest to biochemists and biophysicists.

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This item: Transporters as Drug Carriers: Structure, Function, Substrates

Wiley Encyclopedia of Chemical Biology, 4 Volume Set (Hardcover $1,840.00)

Original Price:$2,088.00

Purchased together:$1,566.00

save $522.00

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PART 1
1 The ABC Transporters: Structural Insights into Drug Transport
2 Biochemistry, Physiology, and Pharmacology of Nucleoside and Nucleobase Transporters
3 Organic Anion Transporting Polypeptides (Oatps/OATPs)
4 CNS Transporters as Drug Targets
PART 2
5 Bacterial Multidrug Transporters: Molecular and Clinical Aspects
6 Pleiotropic drug resistance in yeast and fungal pathogens
PART 3
7 QSAR studies on ABC-transporters: how to deal with polyspecificity
8 Drug Transporter Pharmacophores
PART 4
9 Biological Membranes and Drug Transport
10 Transport at the Blood-Brain Barrier
11 Bile canalicular transporters
12 Interplay of Cytochrome P450 Isoenzymes and ABC-transporter
13 ABC-Transporter: From target to antitarget
PART 3
14 A Systems Biology View of Drug Transporters
15 Drug Transporters in Health and Disease
"Overall, the book is well organized and the topics are clearly and easily accessible. This book offers many strengths ...but overall is quite worthwhile." (ChemMedChem, January 2011)

"Overall, the book is a specialised text (as reflected in the price) that provides a comprehensive review of drug transporters. It would also be a welcome addition to any well stocked university library." (PJ Online, 12 November 2010)