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Vaccinology: An Essential Guide

Vaccinology: An Essential Guide

Gregg N. Milligan (Editor) , Alan D. T. Barrett (Editor)

ISBN: 978-0-470-65616-7

Feb 2015, Wiley-Blackwell

400 pages

In Stock



Vaccinology: An Essential Guide outlines in a clear, practical format the entire vaccine development process, from conceptualization and basic immunological principles through to clinical testing and licensing of vaccines.  With an outstanding introduction to the history and practice of vaccinology, it also guides the reader through the basic science relating to host immune responses to pathogens.

Covering the safety, regulatory, ethical, and economic and geographical issues that drive vaccine development and trials, it also presents vaccine delivery strategies, novel vaccine platforms (including experimental vaccines and pathogens), antigen development and selection, vaccine modelling, and the development of vaccines against emerging pathogens and agents of bioterror. There are also sections devoted to veterinary vaccines and associated regulatory processes.

Vaccinology: An Essential Guide is a perfect tool for designed for undergraduate and graduate microbiologists and immunologists, as well as residents, fellows and trainees of infectious disease and vaccinology. It is also suitable for all those involved in designing and conducting clinical vaccine trials, and is the ideal companion to the larger reference book Vaccinology: Principles and Practice.

Contributors vii

Preface ix

1 The history of vaccine development and the diseases vaccines prevent 1
Martin G. Myers

2 The vaccine development pathway 33
David W.C. Beasley

3 Control and eradication of human and animal diseases by vaccination 43
Nigel Bourne and Gregg N. Milligan

4 Pathogenesis of infectious diseases and mechanisms of immunity 59
Jere W. McBride and David H. Walker

5 The host immune response protective immunity and correlates of protection 73
Gregg N. Milligan

6 Adjuvants: making vaccines immunogenic 93
Gregg N. Milligan

7 Discovery and the basic science phase of vaccine development 109
Gavin C. Bowick

8 Microbial-based and material-based vaccine delivery systems 127
Alfredo G. Torres, Jai S. Rudra and Gregg N. Milligan

9 Licensed vaccines for humans 152
Alan D.T. Barrett

10 Veterinary vaccines 181
A. Paige Adams

11 Development of vaccines for microbial diseases 192
Dennis W. Trent and David W.C. Beasley

12 The regulatory path to vaccine licensure 212
Dennis W. Trent

13 Veterinary vaccines: regulations and impact on emerging infectious diseases 232
A. Paige Adams

14 Vaccine manufacturing 243
Dirk E. Teuwen and Alan D.T. Barrett

15 Clinical evaluation of vaccines 260
Richard E. Rupp and Bridget E. Hawkins

16 Vaccine recommendations and special populations 273
Richard E. Rupp and Bridget E. Hawkins

17 Vaccine safety 287
Dirk E. Teuwen and Alan D.T. Barrett

18 Understanding and measuring the dynamics of infectious disease transmission 304
Christine M. Arcari

19 Vaccines from a global perspective 319
Alan D.T. Barrett and Bridget E. Hawkins

20 Political ethical social and psychological aspects of vaccinology 335
Caroline M. Poland, Robert M. Jacobson, Douglas J. Opel, Edgar K. Marcuse and Gregory A. Poland

Index 358

“It can also serve as a useful reference for practicing physicians and veterinarians who would like to “boost” their knowledge of vaccines.”  (Clinical Infectious Diseases, 6 October 2015)