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Vascular Dementia

John Meyer (Editor), Gaiane Rauch (Editor), Helmut Lechner (Editor), Carlo Loeb (Editor)

ISBN: 978-0-879-93425-5 January 2001 Wiley-Blackwell 310 Pages


Vascular dementia (VAD) accounts for one-third of all dementias in today''s aging population, second only to Alzheimer's disease (DAT). Fortunately, current imaging techniques allow clinicians to view specific lesions in the brain, classify them by etiology and anatomical location, and assess changes using serial imaging, while at the same time correlating those changes with signs and symptoms of VAD or DAT. In 17 chapters, this book summarizes new concepts concerning the epidemiology, etiology, risk factors, neuropathology and pathogenesis of VAD and DAT, and mixtures of the two, and reviews their multiple causes, including microvascular and hemorrhagic lesions, and ischemic and inflammatory changes affecting both white and gray matter.

Contributors iii

Foreword Honorary editor: James F. Toole, President of World Federation of Neurology iv
Preface Editors: John S. Meyer, Gaiane M. Rauch, Helmut Lechner, Carlo Loeb, James F. Toole vi

Chapter 1 Epidemiology of Vascular Dementia 1
Md. Anwarul Haque, John S. Meyer, Gaiane M. Rauch

Chapter 2 Cardiovascular Risk Factors Contributors to Cerebral Degenerative Changes, Cognitive Decline, and Dementia 19
John S. Meyer, Gaiane M. Rauch, Ronald A. Rauch

Chapter 3 Risk Factors for Vascular Dementia 41
Helmut Lechner

Chapter 4 Neuropathological Correlates of Vascular Dementia 59
Carlo Loeb

Chapter 5 Microvascular Pathology in Vascular and Related Dementias 77
Alberto Portera-Sanchez, Jesus Porta-Etessam

Chapter 6 Recent Advances in Vascular Dementia Research 101
David W. Desmond

Chapter 7 Clinical Feautures of Patients with Vascular Dementia Versus Alzheiner’s Disease 119
Gaiane M. Rauch, john S. Meyer

Chapter 8 Neuropsychological Assessments for Cognitive Decline 131
Md. Anwarul Haque, John S. Meyer, Gaiane M. Rauch

Chapter 9 Subcortical Arteriosclerotic Encephalopathy Binswanger Type or Chronic Microvascular Leukoencephalopathy Syndrome 155
Carlo Loeb

Chapter 10 Criteria for Diagnosis of Vascular Dementia 181
Carlo Loeb, John S. Meyer, Gaiane M. Rauch

Chapter 11 Classification of Subtypes of Vascular Dementia Including Subcortical Versus Cortical Dementias 203
John S. Meyer, Gaiane M. Rauch

Chapter 12 Neuroimaging in Vascular Dementia 221
John S. Meyer, Gaiane M. Rauch. Ronald A. Rauch

Chapter 13 Clinical Observation During Long-Term Follow-Up of Outcome in Vascular Dementia 235
Helmut Lechner, Gotz Bertha

Chapter 14 Prevention and Treatment of Vascular Dementia 251
John S. Meyer, Gaiane M. Rauch

Chapter 15 Scientific Basis for Plasmapheresis in Vascular Dementia 263
Helmut Lechner

Chapter 16 Estrogen Therapy for Prevention of Dementia in Postmenopausal Women 279
Gaiane M. Rauch, John S. Meyer

Chapter 17 Factors Influencing Long-Term Survival Among Patients with Vascular Dementia Versus Alzheimer’s Disease 289
John S. Meyer, Gaiane M. Rauch

Index 307