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mRNA Metabolism & Post-Transcriptional Gene Regulation



mRNA Metabolism & Post-Transcriptional Gene Regulation

Joe B. Harford (Editor), David R. Morris (Editor)

ISBN: 978-0-471-14206-5 March 1997 354 Pages

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Edited by Joe B. Harford and David R. Morris

Gene expression is a process that begins with the transcription ofDNA to an RNA messenger (mRNA), which is then translated into aprotein. Historically, attention has been focused on the regulationof RNA synthesis (transcription); however, there is a growingrecognition of and appreciation for the importance of the manyregulatory mechanisms that take place after RNA synthesis has beencompleted.

mRNA Metabolism and Post-Transcriptional Gene Regulation is thefirst comprehensive overview of the various modes of generegulation that exist post-transcriptionally. Collecting studies bysome of the top researchers in the field, this volume provides bothan up-to-date review of the complex "life" of an mRNA molecule andan introduction to current work on the diversity of mechanisms ofpost-transcriptional reactions.

Topics covered include:
* RNA structure
* Mammalian RNA editing
* RNA export from the nucleus
* The fundamentals of translation initiation
* Control of mRNA decay in plants
* mRNA metabolism and cancer
* Control of mRNA stability during herpes simplex virus infection
* Regulation of mRNA expression in HIV-1 and other complexretroviruses
* Nucleases
* RNA localization

A timely contribution to the understanding of genetic regulatorymechanisms, mRNA Metabolism and Post-Transcriptional GeneRegulation provides a basis from which potential therapeuticstrategies may be developed. This book will be of vital interest tocell and molecular biologists at all levels, from graduate studentsto senior investigators, clinical researchers, and professionals inthe pharmaceutical and biotechnology industries.
Partial table of contents:

RNA Structure (E. Puglisi & J. Puglisi).

Transcription and Transcriptional Control: An Overview (I. Olave,et al.).

Constitutive and Alternative mRNA Splicing (S. Bernstein & D.Hodges).

mRNA Polyadenylation: Functional Implications (E. Baker).

RNA Export from the Nucleus (L. Maquat).

The Intracellular mRNA Sorting System: Postal Codes, Zip Codes,Mail Bags and Mail Boxes (O. Steward & R. Singer).

The Fundamentals of Translation Initiation (H. Huang & T.Donahue).

Mechanisms of mRNA Turnover in Eukaryotic Cells (S. Tharun & R.Parker).

Control of mRNA Decay in Plants (A. van Hoof & P. Green).

mRNA Metabolism and Cancer (M. Korth & M. Katze).

Translational Regulation in Animal Virus-Infected Cells (R.Schneider).

RNA Decay by the Interferon-Regulated 2-5A System as a Host DefenseAgainst Viruses (R. Silverman & N. Cirino).

Control of mRNA Stability During Herpes Simplex Virus Infection (G.Read).

Regulation of mRNA Expression in HIV-1 and Other Retroviruses (B.Felber).