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Humanities, Social Sciences, Teacher Education, & STM Rights Catalogue - April 2017

43 To request review copies [email protected] Back to contents Chemistry Oral Bioavailability Assessment Basics and Strategies for Drug Discovery and Development Ayman F. El-Kattan Series: Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods ISBN: 978-1-118-91669-8 | Jul 2017 | 464PP Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability — one of the most significant hurdles in drug discovery and development. •• Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability  •• Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development  •• Explains how preclinical animal models — used in preclinical testing — and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development  •• Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS)  •• Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development About the Author Ayman F. El-Kattan, BPharm, PhD, is Associate Research Fellow in Pfizers Pharmacokinetics, Dynamics, and Metabolism Department, Cambridge Laboratories and an Adjunct Professor at College of Pharmacy-University of Rhode Island in Rhode Island, USA.


Humanities, Social Sciences, Teacher Education, & STM Rights Catalogue - April 2017
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